Anti-inflammatory compounds and methods of use
US-2017096457-A1 · Apr 6, 2017 · US
Anti-inflammatory compounds and methods of use
US11208445B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11208445-B2 |
| Application number | US-202016943763-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 30, 2020 |
| Priority date | May 16, 2014 |
| Publication date | Dec 28, 2021 |
| Grant date | Dec 28, 2021 |
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Abstract
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Methods of treating or inhibiting inflammation in a subject include administering an anti-inflammatory protein to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, SEQ ID NO: 17, or fragments thereof. Isolated polypeptides, nucleic acids, and recombinant vectors including a nucleic acid encoding the anti-inflammatory protein (such as a nucleic acid encoding a protein with at least 80% sequence identity to SEQ ID NO: 1, SEQ ID NO: 17, or fragments thereof) operably linked to a heterologous promoter are also disclosed.
First claim
Opening claim text (preview).
We claim: 1. A method of treating sepsis or septic shock in a subject, comprising administering to the subject a polypeptide comprising: the amino acid sequence of SEQ ID NO: 1; or the amino acid sequence of amino acids 1-185 of SEQ ID NO: 1, amino acids 23-185 of SEQ ID NO: 1, or amino acids 192-313 of SEQ ID NO: 1. 2. The method of claim 1 , wherein the polypeptide consists of: the amino acid sequence of SEQ ID NO: 1; or the amino acid sequence of amino acids 1-185 of SEQ ID NO:1, amino acids 23-185 of SEQ ID NO:1, or amino acids 192-313 of SEQ ID NO:1. 3. The method of claim 1 , wherein the amount of the polypeptide administered to the subject is about 1 mg to about 5 g. 4. The method of claim 1 , wherein the polypeptide is administered to the subject daily, weekly, or monthly. 5. The method of claim 1 , further comprising administering one or more of antibiotics, vasopressors, or intravenous fluids to the subject.
Assignees
Inventors
Classifications
- A61P29/00Primary
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
- C07K14/4702Primary
Regulators; Modulating activity · CPC title
from animals; from humans · CPC title
Vectors or expression systems specially adapted for E. coli · CPC title
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- What does patent US11208445B2 cover?
- Methods of treating or inhibiting inflammation in a subject include administering an anti-inflammatory protein to the subject. In some embodiments, the protein has at least 80% sequence identity to the amino acid sequence set forth as SEQ ID NO: 1, SEQ ID NO: 17, or fragments thereof. Isolated polypeptides, nucleic acids, and recombinant vectors including a nucleic acid encoding the anti-inflam…
- Who is the assignee on this patent?
- Univ Oregon
- What technology area does this patent fall under?
- Primary CPC classification A61P29/00. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Dec 28 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).