3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof

Patent metadata

Field	Value
Publication number	US-11208377-B2
Application number	US-201816103607-A
Country	US
Kind code	B2
Filing date	Aug 14, 2018
Priority date	Aug 14, 2017
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula:The compounds are useful for treating inflammatory and autoimmune diseases.

First claim

What is claimed:

1. A compound of Formula I or a pharmaceutically acceptable salt thereof, including an enantiomer, a diastereoisomer, a tautomer thereof:

wherein
R 1 is
C 1-10 alkyl optionally substituted with at least one group selected from OR 6 , —CO 2 R 6 , and halo;

R 2 is hydrogen;
R 3 is
6 to 12 membered aryl optionally substituted with at least one group selected from C 1-6 alkyl, halo, and OR 6 ;

R 4 is —SO 2 NR 6 R 7 ;
R 5 is halo; and
R 6 and R 7 are independently selected from hydrogen and C 1-6 alkyl.

2. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein R 1 is C 1-10 alkyl substituted with at least one group selected from OR 6 , halo, and —CO 2 R 6 .

3. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein R 6 is hydrogen.

4. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein the moiety:

is of the form:

5. The compound or a pharmaceutically acceptable salt thereof of any one of claim 1 , wherein the moiety:

is of the form:

6. The compound or a pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is

or a pharmaceutically acceptable salt thereof.

Assignees

• Allergan Inc

Inventors

• Hein christopher d
• Duong Tien T
• Sinha Santosh
• Li Ling
• Nguyen Jeremiah H
• Old David W
• Burk Robert
• Viswanath Veena
• Rao Sandhya
• Donello John E

Classifications

• C07C311/43 Primary

  having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring · CPC title

• C07C2602/12

  the other ring being at least seven-membered · CPC title

• C07C2603/70

  containing only six-membered rings · CPC title

• C07B2200/05

  Isotopically modified compounds, e.g. labelled · CPC title

• C07D333/54

  with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring · CPC title