Method and system for delivery of an aerosolized medicament

Patent metadata

Field	Value
Publication number	US-11207475-B2
Application number	US-201716319495-A
Country	US
Kind code	B2
Filing date	Jul 21, 2017
Priority date	Jul 28, 2016
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

The method and system according to preferred embodiments of the present invention allows an effective delivery of aerosolized medicament (e.g., a surfactant) to the patient's lungs. According to a preferred embodiment, the method of the present invention provides an efficient delivery of the aerosol medicament (possibly breath synchronized). A glass vial in which medicaments are usually stored and shipped is used directly as a component of the system. Its function in the system is that of an intermittently pressurized chamber that can inject the surfactant into the catheter of the atomizer device. According to a preferred embodiment the delivery can be done in phase with the beginning of each inspiration. The main elements of the system are: a source of compressed gas, the already mentioned medicament vial, a catheter, and optionally means to detect the breathing pattern and a control unit.

First claim

The invention claimed is:

1. A system purposefully arranged for delivering an aerosolized medicament to a spontaneously breathing patient, comprising:
a source of compressed gas;
a disposable vial partly filled with a liquid medicament;
an assembly adapted to be connected to the disposable vial comprising:
a first channel for conveying the compressed gas to a portion of the disposable vial not containing the liquid medicament; and
a second channel for conveying the liquid medicament from the disposable vial to the patient's lungs; and

means to detect the patient's breath,
wherein, in operation, the compressed gas generates a controllable pressure in the disposable vial which results in the liquid medicament being delivered to the patient's lungs, and
wherein the disposable vial includes:
closing means;
an input needle passing across the closing means, the input needle connecting the first channel with the disposable vial; and
an output needle passing through the closing means, the output needle connecting the disposable vial with the second channel.

2. The system of claim 1 , wherein
a length and a positioning of the input needle is selected so that, in operation, an end of the input needle inside the disposable vial is positioned in the portion of the disposable vial not containing the liquid medicament, and
a length and a positioning of the output needle is selected so that, in operation, all the liquid medicament can flow through the output needle.

3. The system of claim 1 , wherein the closing means includes a rubber cap or a cap of a resilient material suitable to ensure hydraulic seal to the disposable vial even after the input needle and the output needle are in place.

4. The system of claim 1 , wherein the means to detect patient's breath includes pressure detective means, for measuring a value indicative of a pressure in the patient's pharyngeal cavity, such value being used to determine whether the patient is in an inspiration phase or in an expiration phase.

5. The system of claim 1 , wherein the liquid medicament is delivered only when the patient is in the inspiration phase.

6. The system of claim 1 , wherein the liquid medicament includes a pulmonary surfactant.

7. The system of claim 1 , further including an atomizing device.

8. The system of claim 1 , further including a nebulizing device.

9. The system of claim 1 , wherein the disposable vial is made of glass.

10. The system of claim 1 , wherein, in the closing means, the input needle is spaced apart from the output needle.

11. The system of claim 1 , wherein lengths of the input needle and the output needle are selected to allow the compressed gas to be injected where there is already gas in the disposable vial while the liquid medicament is extracted out from the vial.

Assignees

• Chiesi Farm Spa

Inventors

• Dellaca Raffaele
• Milesi Ilaria

Classifications

• A61M15/0091

  mechanically breath-triggered · CPC title

• A61M15/0035

  Piercing means · CPC title

• A61M2205/3331

  Pressure; Flow · CPC title

• A61M16/208

  Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves · CPC title

• B05B7/0483

  with gas and liquid jets intersecting in the mixing chamber · CPC title