Drug diffusing peritoneal dialysis catheter

Patent metadata

Field	Value
Publication number	US-11207453-B2
Application number	US-201916421743-A
Country	US
Kind code	B2
Filing date	May 24, 2019
Priority date	May 24, 2019
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

A peritoneal dialysis catheter includes: a catheter tube defining a lumen for carrying peritoneal dialysis fluid to at least one aperture located at or near a distal end of the lumen; at least one cuff located along the outside of the catheter tube; an access site proximally spaced from the at least one cuff, the access site allowing an antimicrobial agent to be introduced into the catheter tube; a reservoir operable with the catheter tube and in fluid communication with the access site, the reservoir storing an amount of the antimicrobial agent received from the access site after an antimicrobial agent introducer is removed from the access site; and a delivery area of the catheter tube in fluid communication with the reservoir, the delivery area positioned so as to target delivery of the antimicrobial agent to the at least one cuff or other desired location along the catheter tube.

First claim

The invention is claimed as follows:

1. A peritoneal dialysis catheter comprising:
a catheter tube sized to be inserted into a patient's peritoneal cavity, the catheter tube defining a lumen for carrying peritoneal dialysis fluid to at least one aperture located at or near a distal end of the lumen for delivery of the peritoneal dialysis fluid into the patient's peritoneal cavity;
at least one cuff located along the catheter tube for attaching the catheter tube to the patient;
an access site proximally spaced from the at least one cuff so as to remain external to the patient when the at least one cuff is attached to the patient, the access site allowing an antimicrobial agent to be introduced into the catheter tube;
a reservoir in fluid communication with the access site, the reservoir configured to store an amount of the antimicrobial agent received from the access site for delivery after an antimicrobial agent introducer is removed from the access site; and
a delivery area located distal or adjacent to and in fluid communication with the reservoir, the delivery area positioned so as to target delivery of the antimicrobial agent to the at least one cuff.

2. The peritoneal dialysis catheter of claim 1 , wherein the at least one cuff includes first and second cuffs, wherein the delivery area of the catheter tube is a first delivery area positioned so as to target delivery of the antimicrobial agent to the first cuff, and which includes a second delivery area positioned so as to target delivery of the antimicrobial agent from the reservoir to the second cuff.

3. The peritoneal dialysis catheter of claim 2 , wherein the reservoir is in antimicrobial agent flow communication with the first and second delivery areas.

4. The peritoneal dialysis catheter of claim 1 , wherein the access site is configured to seal about the introducer, the introducer including a syringe or cannula.

5. The peritoneal dialysis catheter of claim 1 , wherein the reservoir is an expandable reservoir.

6. The peritoneal dialysis catheter of claim 1 , wherein the reservoir is disposed annularly about at least a portion of the lumen.

7. The peritoneal dialysis catheter of claim 1 , wherein the delivery area is located distal to the reservoir, and wherein the catheter tube defines a flow path leading from the reservoir to the delivery area.

8. The peritoneal dialysis catheter of claim 1 , wherein the delivery area includes first and second delivery areas, and wherein the reservoir is located proximal to the first and second delivery areas or between the first and second delivery areas.

9. The peritoneal dialysis catheter of claim 1 , wherein the delivery area of the catheter tube is at least one of: configured to include minute flow paths leading to the at least one cuff, hydrophilic to the antimicrobial agent, or diffusive to the antimicrobial agent.

10. A peritoneal dialysis catheter comprising:
a catheter tube sized to be inserted into a patient's peritoneal cavity, the catheter tube defining a lumen for carrying peritoneal dialysis fluid to at least one aperture located at or near a distal end of the lumen for delivery of the peritoneal dialysis fluid into the patient's peritoneal cavity;
an access site located so as to remain external to the patient when the catheter tube is attached to the patient, the access site allowing an antimicrobial agent to be introduced into the catheter tube;
a reservoir in fluid communication with the access site, the reservoir configured to store an amount of the antimicrobial agent received from the access site for delivery after an antimicrobial agent introducer is removed from the access site; and
a delivery area located distal to the reservoir, wherein the delivery area is positioned so as to target delivery of the antimicrobial agent to a desired location along the catheter tube, and wherein the catheter tube defines a flow path for the antimicrobial agent, the flow path leading from the reservoir to the delivery area.

11. The peritoneal dialysis catheter of claim 10 , wherein the desired location along the catheter tube includes at least one of (i) a cuff located along the outside of the catheter tube for attaching the catheter tube to the patient, (ii) an exit site of the catheter tube from the patient, or (iii) a subcutaneous area of the catheter tube.

12. The peritoneal dialysis catheter of claim 10 , wherein the delivery area is integrated with a cuff for attaching the catheter tube to the patient.

13. The peritoneal dialysis catheter of claim 10 , wherein the reservoir is an expandable reservoir.

14. The peritoneal dialysis catheter of claim 10 , wherein the reservoir is disposed annularly about at least a portion of the lumen.

15. The peritoneal dialysis catheter of claim 10 , wherein the delivery area includes first and second delivery areas, and wherein the reservoir is located proximal to the first and second delivery areas.

16. The peritoneal dialysis catheter of claim 10 , wherein the delivery area of the catheter tube is at least one of: configured to include minute flow paths leading to at least one cuff, hydrophilic to the antimicrobial agent, or diffusive to the antimicrobial agent.

17. A peritoneal dialysis catheter comprising:
a catheter tube sized to be inserted into a patient's peritoneal cavity, the catheter tube defining a lumen for carrying peritoneal dialysis fluid to at least one aperture located at or near a distal end of the lumen for delivery of the peritoneal dialysis fluid into the patient's peritoneal cavity;
an access site located so as to remain external to the patient when the catheter tube is attached to the patient, the access site allowing an antimicrobial agent to be introduced into the catheter tube;
a reservoir in fluid communication with the access site, the reservoir configured to store an amount of the antimicrobial agent received from the access site for delivery after an antimicrobial agent introducer is removed from the access site;
a first delivery area located adjacent to and in fluid communication with the reservoir, wherein the first delivery area is positioned so as to target delivery of the antimicrobial agent to a first desired location along the catheter tube; and
a second delivery area located distal to and in fluid communication with the reservoir, wherein the second delivery area is positioned so as to target delivery of the antimicrobial agent to a second desired location along the catheter tube, and wherein the catheter tube defines a flow path between the first and second delivery areas.

18. The peritoneal dialysis catheter of claim 17 , wherein the first and second desired locations along the catheter tube include at least one of (i) a cuff located along the outside of the catheter tube for attaching the catheter tube to the patient, (ii) an exit site of the catheter tube from the patient, or (iii) a subcutaneous area of the catheter tube.

19. The peritoneal dialysis catheter of claim 17 , wherein the lumen additionally extends through the second delivery area.

20. A peritoneal dialysis catheter comprising:
a catheter tube sized to be inserted into a patient's peritoneal cavity, the catheter tube defining a lumen for carrying peritoneal dialysis fluid to at least one aperture located at or near a distal end of the lumen for delivery of the peritoneal dialysis fluid into the patient's peritoneal cavity;
an access site located so as to remain external to the patient when the catheter tube is attached to the patient, the access site allowing an antimic

Assignees

• Baxter Int
• Baxter Healthcare Sa

Inventors

• Perry Mark

Classifications

• A61M2025/0056

  provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir · CPC title

• A61M25/003

  characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves (catheter tips A61M25/0067) · CPC title

• A61M1/285 Primary

  Catheters therefor · CPC title

• A61M2025/0293

  Catheter, guide wire or the like with means for holding, centering, anchoring or frictionally engaging the device within an artificial lumen, e.g. tube · CPC title

• A61M25/02

  Holding devices, e.g. on the body · CPC title