Capsule containing functional substance and method for manufacturing said capsule

Patent metadata

Field	Value
Publication number	US-11207258-B2
Application number	US-201716072330-A
Country	US
Kind code	B2
Filing date	Jan 25, 2017
Priority date	Jan 25, 2016
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

It is an object of the present invention to provide a capsule comprising a functional substance and having good shape stability and a good feeling of use. A method for producing a capsule, comprising steps of mixing gelatin and a functional substance; adding a carbodiimide crosslinking agent to crosslink the gelatin with the carbodiimide crosslinking agent; solidifying the crosslinked gelatin; and grinding the solidified gelatin.

First claim

The invention claimed is:

1. A method for producing a capsule, comprising steps of: mixing gelatin and a functional substance, wherein the gelatin has a jelly strength of 110 g to 180 g, and wherein the functional substance has a water solubility of 10 g/L or less, and is selected from the group consisting of: a lignan, a catechin, a flavonol, an anthocyanin, an isoflavone, ferulic acid, and ellagic acid; crosslinking the gelatin by only reacting with a carbodiimide crosslinking agent; solidifying the crosslinked gelatin; and grinding the solidified gelatin to obtain the capsule.

2. The production method according to claim 1 , wherein the gelatin is crosslinked in a solution comprising the carbodiimide crosslinking agent at a concentration of 5 mM to 200 mM.

3. The production method according to claim 1 , wherein the gelatin and the carbodiimide crosslinking agent are reacted at a concentration ratio of 1:0.06 to 1:0.2.

4. The production method according to claim 1 , wherein the carbodiimide crosslinking agent is selected from the group consisting of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, 1-cyclohexyl-3-(2-morpholinyl-4-ethyl)carbodiimide, dicyclohexylcarbodiimide, diisopropylcarbodiimide, and salts thereof.

5. A capsule comprising (i) a functional substance and (ii) gelatin crosslinked only by reacting with a carbodiimide crosslinking agent, wherein the functional substance has a water solubility of 10 g/L or less, and is selected from the group consisting of: a lignan, a catechin, a flavonol, an anthocyanin, an isoflavone, ferulic acid, and ellagic acid, and wherein the gelatin has a jelly strength of 110 g to 180 g.

6. The capsule according to claim 5 , wherein the gelatin has a jelly strength of 135 g to 165 g.

7. The capsule according to claim 5 , wherein the gelatin is acid-treated gelatin.

8. The capsule according to claim 5 , wherein the functional substance is sesamin or ferulic acid.

Assignees

• Suntory Holdings Ltd

Inventors

• Beppu Yoshinori
• Matsuo Yoshihide

Classifications

• B01J13/14

  Polymerisation; cross-linking · CPC title

• C08J2389/06

  derived from leather or skin · CPC title

• A23P10/00

  Shaping or working of foodstuffs characterised by the products · CPC title

• A61K8/73

  Polysaccharides · CPC title

• B01J13/20

  After-treatment of capsule walls, e.g. hardening · CPC title