Method for treating exposed dental pulp

Patent metadata

Field	Value
Publication number	US-11207155-B2
Application number	US-202117352934-A
Country	US
Kind code	B2
Filing date	Jun 21, 2021
Priority date	Sep 12, 2019
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.

First claim

The invention claimed is:

1. A method for treating exposed dental pulp of a tooth in a subject having a damaged tooth, comprising:
applying a treatment composition comprising amelogenin and propylene glycol alginate (“PGA”) to a surface of exposed dental pulp of the tooth; and
applying a permanent dental restorative on top of the treatment composition present on the exposed dental pulp,
wherein the treatment composition comprises 30 mg amelogenin protein powder in mixture with 1 ml of a combination of propylene glycol alginate and a saline matrix.

2. The method of claim 1 , further comprising, after applying the composition, applying a permanent dental restorative on top of the applied composition on a same day.

3. The method of claim 1 , wherein the amelogenin comprises an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2, 4 or 6 or a sequence that has at least 95% sequence identity to SEQ ID NOS: 2, 4 or 6 or a fragment thereof having at least 30 contiguous amino acid residues.

4. The method of claim 1 , wherein the subject is a human and the amelogenin comprises human amelogenin or a fragment thereof having at least 30 contiguous amino acid residues of the human amelogenin.

5. The method of claim 1 , wherein the treatment composition consists essentially of recombinant human amelogenin, the saline and the propylene glycol alginate.

6. The method of claim 1 , wherein the treatment composition further comprises a remineralization agent selected from the group consisting of a material providing calcium ions, a material providing phosphorous ions, and a material providing fluoride ions.

7. The method of claim 1 , wherein said treatment composition further comprises at least one non-amelogenin enamel matrix protein.

8. The method of claim 1 , wherein said treatment composition further comprises at least one bacteriostatic or bactericidal agent.

Assignees

• Univ King Abdulaziz

Inventors

• Bahammam Laila Ahmed Salim
• Mounir Maha M F

Classifications

• A61C5/00

  Filling or capping teeth · CPC title

• A61L2430/12

  for dental implants or prostheses · CPC title

• A61K38/39

  Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] · CPC title

• A61K6/898

  Polysaccharides · CPC title

• A61K6/69

  Medicaments · CPC title