Preservative containing compositions

Patent metadata

Field	Value
Publication number	US-11202832-B2
Application number	US-202016808566-A
Country	US
Kind code	B2
Filing date	Mar 4, 2020
Priority date	Mar 4, 2016
Publication date	Dec 21, 2021
Grant date	Dec 21, 2021

Abstract

The present invention relates to compositions providing improved preservative efficacy. The present invention further relates to polyquaternium compound containing compositions having improved the antifungal activity. In certain embodiments, the present invention relates to ophthalmic compositions comprising a polyquaternium compound, a polyol or combination of polyols, borate compound, and an antimicrobial mixture comprising electrolytes and nutrients.

First claim

What is claimed is:

1. A composition comprising the following formulation:
a. from about 0.01% w/v to about 0.2% w/v vasoconstictor;
b. from about 0.0015% w/v to about 0.0036% w/v polyquaternium 42;
c. from about 0.2% w/v to about 1.2% w/v polyethylene glycol 400;
d. from about 0.2% w/v to about 1.3% w/v glycerin;
e. from about 0.004% w/v to about 0.6% w/v borate;
f. from about 0.05% w/v to about 0.2% w/v lactate or pharmaceutically acceptable salt thereof;
g. from about 0.003% w/v to about 0.4% w/v glucose;
h. from about 0% w/v to about 2.5% w/v hypromellose; and
i. water.

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Bai Mingqi
• Holeva Kenneth T

Classifications

• A61P31/10

  Antimycotics · CPC title

• A61P29/02

  without antiinflammatory effect · CPC title

• A61K47/38 Primary

  Cellulose; Derivatives thereof · CPC title

• A61K33/22

  Boron compounds · CPC title

• A61K33/14

  Alkali metal chlorides; Alkaline earth metal chlorides · CPC title