Dihydronaphthalene derivative
US-2017327439-A1 · Nov 16, 2017 · US
US11198672B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11198672-B2 |
| Application number | US-201916970865-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 21, 2019 |
| Priority date | Feb 22, 2018 |
| Publication date | Dec 14, 2021 |
| Grant date | Dec 14, 2021 |
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A compound represented by the general formula (V)wherein all the symbols are as defined in the specification, has an improved balance of the agonist activity against the S1P5 receptor relative to the S1P1 receptor, and can thus serve as a therapeutic agent for S1P5-mediated diseases such as schizophrenia and Binswanger's disease and other neurodegenerative diseases.
Opening claim text (preview).
The invention claimed is: 1. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is 1-[[(3S)-3-methyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof. 2. A compound of the following structure: 3. A pharmaceutically acceptable salt of the compound of the following structure:
containing six-membered aromatic rings and other rings · CPC title
having no double bonds between ring members or between ring members and non-ring members · CPC title
Drugs for immunological or allergic disorders · CPC title
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
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