Compounds having S1P5 receptor agonistic activity

US11198672B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11198672-B2
Application numberUS-201916970865-A
CountryUS
Kind codeB2
Filing dateFeb 21, 2019
Priority dateFeb 22, 2018
Publication dateDec 14, 2021
Grant dateDec 14, 2021

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

A compound represented by the general formula (V)wherein all the symbols are as defined in the specification, has an improved balance of the agonist activity against the S1P5 receptor relative to the S1P1 receptor, and can thus serve as a therapeutic agent for S1P5-mediated diseases such as schizophrenia and Binswanger's disease and other neurodegenerative diseases.

First claim

Opening claim text (preview).

The invention claimed is: 1. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is 1-[[(3S)-3-methyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof. 2. A compound of the following structure: 3. A pharmaceutically acceptable salt of the compound of the following structure:

Assignees

Inventors

Classifications

  • containing six-membered aromatic rings and other rings · CPC title

  • C07D205/04Primary

    having no double bonds between ring members or between ring members and non-ring members · CPC title

  • Drugs for immunological or allergic disorders · CPC title

  • Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals · CPC title

  • C07D403/04Primary

    directly linked by a ring-member-to-ring-member bond · CPC title

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Frequently asked questions

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What does patent US11198672B2 cover?
A compound represented by the general formula (V)wherein all the symbols are as defined in the specification, has an improved balance of the agonist activity against the S1P5 receptor relative to the S1P1 receptor, and can thus serve as a therapeutic agent for S1P5-mediated diseases such as schizophrenia and Binswanger's disease and other neurodegenerative diseases.
Who is the assignee on this patent?
Ono Pharmaceutical Co
What technology area does this patent fall under?
Primary CPC classification C07D205/04. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).