Apparatus and method for detecting disconnection of an intravascular access device

Patent metadata

Field	Value
Publication number	US-11197951-B2
Application number	US-201916263950-A
Country	US
Kind code	B2
Filing date	Jan 31, 2019
Priority date	Oct 30, 2009
Publication date	Dec 14, 2021
Grant date	Dec 14, 2021

Abstract

An apparatus and method are disclosed for detecting the disconnection of a vascular access device such as a needle, cannula or catheter from a blood vessel or vascular graft segment. A pair of electrodes is placed in direct contact with fluid or blood in fluid communication with the vascular segment. In one embodiment, the electrodes are incorporated into a pair of connectors connecting arterial and venous catheters to arterial and venous tubes leading to and from an extracorporeal blood flow apparatus. Wires leading from the electrodes to a detecting circuit can be incorporated into a pair of double lumen arterial and venous tubes connecting the blood flow apparatus to the blood vessel or vascular graft. The detecting circuit is configured to provide a low-voltage alternating current signal to the electrodes to measure the electrical resistance between the electrodes, minimizing both the duration and amount of current being delivered. Detection of an increase in electrical resistance between the electrodes exceeding a pre-determined threshold value may be used to indicate a possible disconnection of the vascular access device.

First claim

The invention claimed is:

1. An electrical circuit for measuring the resistance of a liquid between a first and second electrode, the first electrode connected to a first terminal of the electrical circuit, and the second electrode connected to a second terminal of the electrical circuit, comprising:
a capacitor C 1 connected on a first end to the first terminal and a capacitor C 2 connected on a first end to the second terminal;
a known reference resistance Rref connected on a first end to a second end of capacitor C 1 ;
switching means for connecting either;
a) a first reference voltage V+ to a second end of Rref, and a lower second reference voltage V− to a second end of C 2 to form a first switch configuration or;
b) the first reference voltage V+ to the second end of C 2 and the lower second reference voltage V− to the second end of Rref to form a second switch configuration; and measuring means for measuring a voltage Vsense at the connection between C 1 and Rref; wherein
the electrical circuit is configured to determine the value of the resistance of the liquid based on the known reference resistance Rref and the observed voltage Vsense for each of the first and second switch configurations.

2. The electrical circuit of claim 1 , wherein the resistance-Rref is chosen to permit conductivity measurement of an electrolyte solution suitable for intravascular infusion.

3. The electrical circuit of claim 2 , wherein the electrolyte solution comprises dialysate solution.

4. The electrical circuit of claim 1 , wherein the resistance Rref is chosen to permit measurement of the resistance of a volume of blood between the first and second electrodes.

5. A system for detecting the disconnection of a vascular access device from a blood vessel or vascular graft, comprising:
a fluid delivery device for providing liquid through a first conduit into a first site of the blood vessel or graft, and for receiving fluid through a second conduit from a second site of the blood vessel or graft;
wherein the first electrode is in fluid communication with a lumen of the first conduit;
wherein the second electrode is in fluid communication with a lumen of the second conduit;
the system further comprising the electrical circuit of claim 1 .

6. The system of claim 5 , wherein the first and second electrodes are located closer to the blood vessel or graft than to the fluid delivery device.

7. The system of claim 5 , further comprising a low pass filter connected between the measuring means and said connection between C 1 and Rref where Vsense is measured.

8. The system of claim 7 , wherein the low pass filter includes a resistor and capacitor to filter high-frequency noise.

9. The system of claim 5 , wherein the measuring means includes a buffer amplifier and an analog-to-digital converter.

10. The system of claim 5 , wherein the switching means includes first and second multiplexers.

11. The system of claim 10 , wherein the first and second multiplexers are driven by respective alternating binary control signals.

12. The system of claim 10 , wherein the first and second multiplexers each have a first input connected to the first reference voltage V+ and a second input connected to the second reference voltage V−.

13. The system of claim 5 , further comprising a voltage divider that creates the first and second reference voltages.

14. The system of claim 13 , wherein the voltage divider is provided with a main reference voltage Vref from which the voltage divider creates the first and second reference voltages.

15. The system of claim 14 , wherein the first reference voltage is greater than the second reference voltage, and wherein the first reference voltage is close to the main reference voltage Vref and the second reference voltage is close to a ground reference voltage.

16. The system of claim 5 , wherein the switching means is operated to alternate between the first and second switch configurations and the measuring means is arranged to measure Vsense before and after each time the switching network changes between the first and second switch configurations.

17. The system of claim 5 , wherein the resistance of resistor Rref is selected to be a geometric mean of endpoints of a range of resistances to be determined by the electrical circuit.

18. The system of claim 17 , wherein the range of resistances to be determined by the electrical circuit includes series resistances Rs.

19. The system of claim 5 , further comprising a calibration switch.

20. The system of claim 5 , wherein the capacitors C 1 and C 2 block DC current from passing through a path between the first and second terminals.

21. The system of claim 5 , wherein each of said first and second electrodes is electrically connected to a corresponding one of the first and second terminals of the electronic circuit through a wire located in a second lumen of a double lumen tube, a first lumen of said double lumen tube configured to carry blood between the fluid delivery device and the first or second site.

22. The system of claim 5 wherein the first and second conduits are flexible tubes and the system further comprises a first connector configured to connect the first conduit to a first catheter, and a second connector configured to connect the second conduit to a second catheter, each connector having an electrode in fluid communication with a lumen of said connector.

Assignees

• Deka Products Lp

Inventors

• Wilt Michael J
• Sachs Jason M

Classifications

• A61M1/3655

  Arterio-venous shunts or fistulae · CPC title

• G01R27/14

  Measuring resistance by measuring current or voltage obtained from a reference source (G01R27/16, G01R27/20, G01R27/22 take precedence) · CPC title

• G01N27/07

  Construction of measuring vessels; Electrodes therefor · CPC title

• A61M1/3656 Primary

  Monitoring patency or flow at connection sites; Detecting disconnections · CPC title

• A61M2205/3317

  Electromagnetic, inductive or dielectric measuring means · CPC title