Genetically modified bacillus subtilis strain and use as a live delivery and production system
US-2024390433-A1 · Nov 28, 2024 · US
US11197898B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11197898-B2 |
| Application number | US-201916410054-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 13, 2019 |
| Priority date | May 13, 2019 |
| Publication date | Dec 14, 2021 |
| Grant date | Dec 14, 2021 |
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The present invention discloses a novel fructophilic lactic acid producing bacteria Bacillus coagulans strain FF-7 (MTCC 25235) and the process of isolation and characterization of the bacteria. The invention also discloses the biological applications/therapeutic use of fructophilic lactic acid producing bacteria in increased utilization of fructose from food stuff and in the managing disorders related to high fructose intake.
Opening claim text (preview).
We claim: 1. A method of increasing utilization of fructose in food stuff, said method comprising step of bringing into contact foods rich in fructose with probiotic bacteria Bacillus coagulans MTCC 25235, to bring about an effect of increased utilization of fructose or to decrease the content of fructose from foods rich in fructose. 2. The method as in claim 1 , wherein the said probiotic bacterium is isolated from honey. 3. The method as in claim 1 , wherein the foods rich in fructose are selected from the group consisting of high fructose corn syrup, honey, Agave, Maple syrup, Coconut sugar, Palm sugar, Molasses, Soda, Candies, sweetened yogurt, frozen foods, canned foods, cereals, fruit juices, coffee creamer, jams and jellies, energy drinks, condiments, ice cream. 4. The method as in claim 1 , wherein increased utilization of fructose is effective for the therapeutic management of disorders related to high fructose intake. 5. The method as in claim 4 , wherein the disorders related to high fructose intake are selected from the group consisting of, obesity, non-alcoholic steatohepatitis (NASH), insulin resistance, metabolic syndrome, cardio-vascular complications, diabetes, hyperlipidemia, hypertension, inflammation and hyperuricemia. 6. The method as in claim 1 , wherein the probiotic bacteria is present in the form of an inoculum, freeze-dried powder, fine powder, tablet, capsule, suspension, solution, emulsion, gummy, chewable or edible foods and administered as a stand alone or in combination with foods rich in fructose selected from the group consisting of high fructose corn syrup, honey, Agave, Maple syrup, Coconut sugar, Palm sugar, Molasses, Soda, Candies, sweetened yogurt, frozen foods, canned foods, cereals, fruit juices, coffee creamer, jams and jellies, energy drinks, condiments, ice cream.
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)} · CPC title
Bacillus · CPC title
Bacteria or derivatives thereof, e.g. probiotics · CPC title
Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes · CPC title
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