Powder injection of the donepezil semi palmoxiric acid salt, composition containing same and preparation method therefor

Patent metadata

Field	Value
Publication number	US-11197850-B2
Application number	US-201816465116-A
Country	US
Kind code	B2
Filing date	Feb 13, 2018
Priority date	Feb 23, 2017
Publication date	Dec 14, 2021
Grant date	Dec 14, 2021

Abstract

A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals, and the average grain size of the crystals ranges from 0.5 μm to 100 μm.

First claim

The invention claimed is:

1. A powder injection of donepezil semi pamoate comprising donepezil semi pamoate crystals, wherein the donepezil semi pamoate crystals have an average particle size of 2-52 μm, wherein the donepezil semi pamoate crystals have an angle of repose of 25-46 degrees, and wherein an injection prepared from the powder injection has less stimulation to the muscle after injection.

2. A method for preparing the powder injection of donepezil semi pamoate of claim 1 , comprising:
step 1: dissolving donepezil hydrochloride in purified water, stirring, and filtering to obtain a filtrate;
step 2: dissolving disodium pamoate in purified water, stirring, and filtering to obtain a filtrate; and
step 3: adding donepezil semi pamoate seed crystals to the filtrate obtained in step 1 to obtain a solution, then dropwise adding the filtrate obtained in step 2 to the solution, stirring for 1-2 hours to crystallize donepezil semi pamoate, filtering to obtain a filter cake, washing the filter cake with purified water, drying, and performing a dry pulverization and a sterilization process;
wherein the sterilization process is a γ-ray irradiation sterilization, an electron beam irradiation sterilization or a microwave irradiation sterilization, and an irradiation dose of the irradiation sterilization is 25 kGy to 60 kGy.

Assignees

• Shanghai Synergy Pharmaceutical Sciences Co Ltd
• Zhejiang Huahai Pharm Co Ltd

Inventors

• Ge Jian
• Li Yunfei
• Lin Lihong
• Sun Dengxue
• Wang Jiamiao
• Wang Yijin
• Wang Zhiyun

Classifications

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61K31/445 Primary

  Non condensed piperidines, e.g. piperocaine · CPC title

• A61K47/02

  Inorganic compounds · CPC title