Situ filling and sealing of electrowetting intraocular lenses

Patent metadata

Field	Value
Publication number	US-11197752-B2
Application number	US-201815945880-A
Country	US
Kind code	B2
Filing date	Apr 5, 2018
Priority date	May 5, 2017
Publication date	Dec 14, 2021
Grant date	Dec 14, 2021

Abstract

An eye-implantable electrowetting lens can be operated to control an overall optical power of an eye in which the device is implanted. A lens chamber of the electrowetting lens contains first and second fluids that are immiscible with each other and have different refractive indexes. By applying a voltage to electrodes of the lens, the optical power of the lens can be controlled by affecting the geometry of the interface between the fluids. When the electrowetting lens is inserted into the eye, the lens chamber may contain only one of the first and second fluids. The other fluid can be added after insertion through a needle, a tube, or some other means. Having only one of the first and second fluids in the lens chamber during insertion of the lens can prevent fouling of internal surfaces due to folding or other manipulation of the lens during the insertion process.

First claim

What is claimed is:

1. An eye-implantable device comprising:
an electrowetting lens, wherein the electrowetting lens comprises:
a lens chamber;
a polymeric material, wherein the polymeric material at least partially encloses the lens chamber;
a first electrode, wherein the first electrode is disposed on a first internal surface of the polymeric material;
a second electrode, wherein the second electrode is disposed on a second internal surface of the polymeric material, wherein the second electrode comprises a dielectric coating; and
a septum, wherein the septum blocks a fluid pathway into the lens chamber from outside of the eye-implantable device, such that the septum can be penetrated and a first fluid introduced into the lens chamber through the fluid pathway from outside of the eye-implantable device such that the first fluid contacts the second electrode but not the first electrode.

2. The eye-implantable device of claim 1 , further comprising a second fluid, wherein the second fluid is disposed in the lens chamber, wherein the first electrode and the second electrode are in contact with the second fluid.

3. The eye-implantable device of claim 2 , wherein the polymeric material is flexible such that the electrowetting lens can be folded.

4. The eye-implantable device of claim 2 , wherein the fluid pathway comprises a channel between the septum and the lens chamber.

5. The eye-implantable device of claim 2 , wherein the septum comprises a silicone rubber.

6. An eye-implantable device comprising:
an electrowetting lens, wherein the electrowetting lens comprises:
a lens chamber;
a polymeric material, wherein the polymeric material at least partially encloses the lens chamber;
a first electrode, wherein the first electrode is disposed on a first internal surface of the polymeric material;
a second electrode, wherein the second electrode is disposed on a second internal surface of the polymeric material, wherein the second electrode comprises a dielectric coating; and
a tube that protrudes from the eye-implantable device, wherein the tube provides at least a portion of a fluid pathway into the lens chamber from outside of the eye-implantable device, such that a first fluid can be introduced into the lens chamber through the tube from outside of the eye-implantable device such that the first fluid contacts the second electrode but not the first electrode.

7. The eye-implantable device of claim 6 , further comprising a second fluid, wherein the second fluid is disposed in the lens chamber, wherein the first electrode and the second electrode are in contact with the second fluid.

8. The eye-implantable device of claim 7 , wherein the polymeric material is flexible such that the electrowetting lens can be folded.

9. The eye-implantable device of claim 7 , wherein the tube includes a crimpable portion, and wherein crimping the crimpable portion of the tube inhibits fluid flow out of the eye-implantable device via the tube.

10. A method comprising:
forming an incision through a cornea of an eye;
inserting an eye-implantable device into the eye through the incision, wherein the eye-implantable device comprises:
an electrowetting lens, wherein the electrowetting lens comprises: (i) a lens chamber, (ii) a polymeric material, wherein the polymeric material at least partially encloses the lens chamber, (iii) a first electrode, wherein the first electrode is disposed on a first internal surface of the polymeric material, (iv) a second electrode, wherein the second electrode is disposed on a second internal surface of the polymeric material, wherein the second electrode comprises a dielectric coating, and (v) a septum, wherein the septum blocks a fluid pathway into the lens chamber of the electrowetting lens from outside of the eye-implantable device;

placing the eye-implantable device at a specified location within the eye;
piercing the septum with a needle; and
introducing a second fluid into the lens chamber via the needle when a first fluid is already present in the lens chamber such that the second fluid contacts the second electrode but not the first electrode, wherein the second fluid is immiscible with the first fluid, and wherein a refractive index of the second fluid differs from a refractive index of the first fluid.

11. The method of claim 10 , wherein the electrowetting lens is flexible such that the electrowetting lens can be folded, wherein inserting an eye-implantable device into the eye through the incision comprises inserting the eye-implantable device in a folded state, and further comprising:
subsequent to inserting the eye-implantable device into the eye through the incision, unfolding the electrowetting lens of the eye-implantable device.

12. The method of claim 11 , wherein the incision is less than 4 millimeters long.

13. The method of claim 10 , further comprising rinsing the lens chamber, wherein rinsing the lens chamber comprises introducing an amount of the first fluid into the lens chamber via the needle.

14. The method of claim 10 , wherein the eye-implantable device further comprises a tube that protrudes from the eye-implantable device, wherein the tube provides at least a portion of the fluid pathway into the lens chamber from outside of the eye-implantable device, and wherein the method further comprises:
crimping the tube, wherein crimping the tube inhibits fluid flow out of the eye-implantable device via the tube.

15. A method comprising:
forming an incision through a cornea of an eye;
inserting an eye-implantable device into the eye through the incision, wherein the eye-implantable device comprises:
an electrowetting lens, wherein the electrowetting lens comprises: (i) a lens chamber, (ii) a polymeric material, wherein the polymeric material at least partially encloses the lens chamber, (iii) a first electrode, wherein the first electrode is disposed on a first internal surface of the polymeric material, (iv) a second electrode, wherein the second electrode is disposed on a second internal surface of the polymeric material, wherein the second electrode comprises a dielectric coating, and (v) a tube that protrudes from the eye-implantable device, wherein the tube provides at least a portion of a fluid pathway into the lens chamber of the electrowetting lens from outside of the eye-implantable device;

placing the eye-implantable device at a specified location within the eye;
introducing a second fluid into the lens chamber via the tube when a first fluid is already present in the lens chamber such that the second fluid contacts the second electrode but not the first electrode, wherein the second fluid is immiscible with the first fluid, and wherein a refractive index of the second fluid differs from a refractive index of the first fluid; and
cutting the tube.

16. The method of claim 15 , wherein the electrowetting lens is flexible such that the electrowetting lens can be folded, wherein inserting an eye-implantable device into the eye through the incision comprises inserting the eye-implantable device in a folded state, and further comprising:
subsequent to inserting the eye-implantable device into the eye through the incision, unfolding the electrowetting lens of the eye-implantable device.

17. The method of claim 16 , wherein the incision is less than 4 millimeters long.

18. The method of claim 15 , further comprising crimping the tube, wherein crimping the tube inhibits fluid flow out of the eye-implantable device via the tube.

19. The method of claim 15 , further comprising rin

Assignees

• Verily Life Sciences Llc

Inventors

• Otts Daniel
• Kuiper Stein

Classifications

• A61F2250/0015

  differing in density or specific weight · CPC title

• A61F2/1635 Primary

  for changing shape · CPC title

• A61F2250/0003

  having an inflatable pocket filled with fluid, e.g. liquid or gas · CPC title

• A61F2250/0001

  Means for transferring electromagnetic energy to implants · CPC title

• G02B26/005

  based on electrowetting · CPC title