Treatment of H. pylori infections using MTAN inhibitors
US-10118928-B2 · Nov 6, 2018 · US
US11186575B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11186575-B2 |
| Application number | US-201314419669-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 7, 2013 |
| Priority date | Aug 7, 2012 |
| Publication date | Nov 30, 2021 |
| Grant date | Nov 30, 2021 |
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Methods of treating infections due to Helicobacter pylori ( H. pylori ), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering to the subject an inhibitor of H. pylori MTAN (5′-methylthioadenosine nucleosidase) having the structure of formula (I)
Opening claim text (preview).
What is claimed is: 1. A compound selected from the group consisting of or a pharmaceutically acceptable salt thereof, or an ester thereof. 2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 3. A method of treating a Helicobacter pylori ( H. pylori ) infection in a subject in need thereof comprising administering to the subject a compound of claim 1 in an amount effective to inhibit growth of H. pylori. 4. The method of claim 3 , wherein the subject has a peptic ulcer. 5. The method of claim 3 , wherein the subject has a gastric ulcer or a duodenal ulcer. 6. The method of claim 3 , wherein the compound is administered orally.
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