Phenylpyrrolidinone formyl peptide 2 receptor agonists
US-2020255375-A1 · Aug 13, 2020 · US
US11186544B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11186544-B2 |
| Application number | US-201816619956-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 8, 2018 |
| Priority date | Jun 9, 2017 |
| Publication date | Nov 30, 2021 |
| Grant date | Nov 30, 2021 |
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The disclosure relates to compounds of formula (I), which are formyl peptide 2 (FPR2) receptor agonists and/or formyl peptide 1 (FPR1) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
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What is claimed is: 1. A compound of selected from the group consisting of or a pharmaceutically acceptable salt thereof. 2. A compound selected from the group consisting of or a pharmaceutically acceptable salt thereof. 3. A compound selected from the group consisting of or a pharmaceutically acceptable salt thereof. 4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 5. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. 6. A pharmaceutical composition comprising a compound of claim 3 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient.
linked by a carbon chain containing aromatic rings · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
linked by a carbon chain containing aromatic rings · CPC title
linked by a carbon chain containing aromatic rings · CPC title
containing three or more hetero rings · CPC title
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