Finished fibrous structures and methods of their use and preparation

Patent metadata

Field	Value
Publication number	US-11185495-B2
Application number	US-201816178147-A
Country	US
Kind code	B2
Filing date	Nov 1, 2018
Priority date	Nov 1, 2017
Publication date	Nov 30, 2021
Grant date	Nov 30, 2021

Abstract

The disclosure is directed to fibrous structures finished with active pharmaceutical ingredients, as well as methods of their manufacturer and use.

First claim

What is claimed:

1. A method of locally, systemically, or locally and systemically, administering a therapeutically effective amount of an active pharmaceutical ingredient to a subject in need thereof comprising:
applying a garment that is a mechanically dewatered, finished, non-occlusive, pharmaceutical fibrous structure to the intact skin of the subject for a time sufficient to locally administer, systemically administer, or both locally and systemically administer the therapeutically effective amount of the active pharmaceutical ingredient to the subject,
the garment comprising natural fibers, manmade fibers, synthetic fibers, or a mixture thereof,
wherein the garment has been finished with a finishing composition that is a homogeneous dispersion comprising
an active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof,
a solvent;
a surfactant;
optionally, a humectant; and
optionally, a permeation enhancer;

wherein the garment is finished by being caused to interact with the homogeneous dispersion by at least one of diffusion of the homogeneous dispersion into the garment fibers, deposition of the homogeneous dispersion onto the surfaces of the garment fibers, and deposition of the homogeneous dispersion onto the interstices between the garment fibers; and
wherein the dry weight of the mechanically dewatered, finished, non-occlusive, pharmaceutical fibrous structure is increased at least about 20% Add-on, as compared to the dry weight of the fibrous structure absent the finishing treatment.

2. The method of claim 1 wherein the active pharmaceutical ingredient is lidocaine, prilocaine, bupivacaine, mepivacaine, ropivacaine, articaine, tetracaine, capsaicin, diclofenac, menthol, methyl salicylate, salicylic acid, scopolamine, nitroglycerin, clonidine, estradiol, estradiol/norethidrone, ethinyl estradiol/norelgestromin, estradiol/levonorgestrel fentanyl, nicotine, testosterone, oxybutynin, prilocaine, methylphenidate, betamethasone, buprenorphine, triclocarban, acyclovir, adapalene, allantoin, benzocaine, bexarotene, brimonidine, calcipotriene, calcitriol, ciclopirox, clindamycin, clobetasol, dapsone, diphenhydramine, doxepin, econazole, fluocinolone, fluticasone, halobetasol, hydrocortisone, imiquimod, ingenol, ivermectin, ketoconazole, loteprednol, luliconazole, mafenide, methyl salicylate, metronidazole, miconazole, minoxidil, mometasone, mupirocin, neomycin, nystatin, penciclovir, phenylephedrine, pimecrolimus, pramoxine, selenium, sulconazole, sulfacetamide, tacrolimus, tavaborole, tetracycline, tioconazole, tretinoin, triamcinolone, triclosan, selegiline, rotigotine, rivastigmine, terbinafine, clotrimazole, detomidine, medetomidine, dexmedetomidine, or a combination thereof.

3. The method of claim 1 , wherein the garment is applied to the subject's intact skin for a time period that is between about 1 hour and about 72 hours.

4. The method of claim 1 , wherein the therapeutically effective amount is administered to the subject throughout the time period.

5. The method of claim 1 , wherein the garment is applied to the subject's intact skin continuously throughout the time period.

6. The method of claim 1 , wherein the garment is applied to the subject's intact skin intermittently throughout the time period.

7. The method of claim 1 , for the treatment of pain.

8. The method of claim 7 , wherein the pain is neuropathic pain.

9. The method of claim 7 , wherein the pain is postherpetic neuralgia or painful diabetic neuropathy, pain associated with chemotherapy, pain associated with HIV, erythromelalgia, pain associated with osteoarthritis, or lower back pain.

10. The method of claim 1 , for the treatment of a microbial infection or a fungal infection.

11. The method of claim 1 , for the treatment of an allergy, atopic dermatitis, psoriasis, chronic inflammation, or acute inflammation.

12. The method of claim 1 , wherein the garment is finished by being caused to interact with the homogeneous dispersion by diffusion of the homogeneous dispersion into the garment fibers.

13. The method of claim 1 , wherein the garment is finished by being caused to interact with the homogeneous dispersion by deposition of the homogeneous dispersion onto the surfaces of the garment fibers.

14. The method of claim 1 , wherein the garment is finished by being caused to interact with the homogeneous dispersion by deposition of the homogeneous dispersion onto the interstices between the garment fibers.

15. The method of claim 1 , wherein the garment is in the form of a glove, sock, shirt, pant, cap, underpant, brassier, or band.

16. The method of claim 15 , wherein the band is an armband, legband, headband, wristband, backbelt, kneeband, ankleband, elbowband, or neckband.

17. The method of claim 1 , wherein the garment is in the form of a sock.

18. The method of claim 1 , wherein the garment is in the form of a t-shirt.

19. The method of claim 1 , wherein the garment is in the form of a glove.

20. The method of claim 1 , wherein the garment is in the form of a band.

Assignees

• Clexio Biosciences Ltd

Inventors

• Koren Erez
• Shalev Itzhak
• Zamansky Mark

Classifications

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61L15/44

  Medicaments · CPC title

• A61P23/02

  Local anaesthetics · CPC title

• A61K31/4174

  Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole · CPC title

• A61F13/00063

  comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00) · CPC title