Method of blocking vascular leakage using an anti-ANG2 antibody
US-9902767-B2 · Feb 27, 2018 · US
Anti-ANG2 antibody
US11174309B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11174309-B2 |
| Application number | US-201715823272-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 27, 2017 |
| Priority date | Jul 29, 2013 |
| Publication date | Nov 16, 2021 |
| Grant date | Nov 16, 2021 |
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- Title
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Abstract
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An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
First claim
Opening claim text (preview).
What is claimed is: 1. A method of activating Tie-2 receptor in a subject, comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof to the subject to form a complex comprising the anti-Ang2 antibody or the antigen-binding fragment thereof, Ang2, and a Tie2 receptor, while inducing Tie2 phosphorylation, wherein the anti-Ang2 antibody or the antigen-binding fragment thereof comprises: heavy chain complementarity determining regions (CDRs) comprising a polypeptide (CDR-H1) comprising the amino acid sequence of SEQ ID NO: 1, a polypeptide (CDR-H2) comprising the amino acid sequence of SEQ ID NO: 2, and a polypeptide (CDR-H3) comprising the amino acid sequence of SEQ ID NO: 3; and light chain complementarity determining regions comprising a polypeptide (CDR-L1) comprising the amino acid sequence of SEQ ID NO: 4, a polypeptide (CDR-L2) comprising the amino acid sequence of SEQ ID NO: 5, and a polypeptide (CDR-L3) comprising the amino acid sequence of SEQ ID NO: 6. 2. The method of claim 1 , wherein the anti-Ang2 antibody or the antigen-binding fragment thereof comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 7, and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 9. 3. The method of claim 1 , wherein the anti-Ang2 antibody is a monoclonal antibody. 4. The method of claim 3 , wherein the anti-Ang2 antibody is obtained from a hybridoma deposited with accession number KCLRF-BP-00295. 5. The method of claim 1 , further comprising administering Ang2 to the subject.
Assignees
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Classifications
Immunosuppressants, e.g. drugs for graft rejection · CPC title
Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title
Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues · CPC title
for growth factors; for growth regulators · CPC title
- C07K16/22Primary
against growth factors {; against growth regulators} · CPC title
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- What does patent US11174309B2 cover?
- An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.
- Who is the assignee on this patent?
- Samsung Electronics Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification C07K16/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).