Catalyst for preparing α-phenylethanol by hydrogenation of acetophenone, preparation method thereof and application thereof

Patent metadata

Field	Value
Publication number	US-11167280-B2
Application number	US-201816763865-A
Country	US
Kind code	B2
Filing date	Jun 29, 2018
Priority date	Dec 6, 2017
Publication date	Nov 9, 2021
Grant date	Nov 9, 2021

Abstract

Disclosed is catalyst preparation method for liquid phase hydrogenation of acetophenone in preparation of α-phenylethanol. The method includes adding water, small alcohol, Gemini surfactant and organic pore-forming agent to reactor. Then adding silica sol and stirring to prepare aqueous dispersion of silica sol; preparing alkaline precipitant and mixed solution containing salts of copper containing compound, zinc containing compound, rare-earth metal containing compound and alkaline-earth metal containing compound, adding alkaline precipitant and mixed solution together to aqueous dispersion, followed by precipitation, ageing, filtration, washing, drying, calcination and molding to obtain catalyst. By using silica sol and silicate as composite silicon source, adding organic pore-forming agent before precipitation process, modifying catalyst by Zn, rare-earth metal and alkaline earth metal, when using liquid phase hydrogenation of acetophenone to prepare α-phenylethanol, catalyst has high activity and good selectivity, and effectively improves the catalyst's liquid resistance, has high strength and good stability.

First claim

The invention claimed is:

1. A preparation method for a hydrogenation catalyst, comprising the following steps:
(1) adding water, a small molecule alcohol, a Gemini surfactant and an organic pore-forming agent to a reactor, followed by adding a silica sol and stirring the mixture well to prepare an aqueous dispersion of silica sol containing the small molecule alcohol, the Gemini surfactant and the organic pore-forming agent;
(2) dissolving a salt of a copper containing compound, a salt of a zinc containing compound, a salt of a rare-earth metal containing compound and a salt of an alkaline-earth metal containing compound in water to prepare a solution of mixed salt; dissolving a silicon containing alkaline precipitant and a silicon free alkaline precipitant in water to prepare an aqueous solution of alkaline precipitant; adding the solution of mixed salt and the aqueous solution of alkaline precipitant together to the aqueous dispersion of silica sol for reaction, with the pH of the reaction system during the reaction process being controlled at 5.0-9.0, and followed by aging to obtain a slurry;
(3) filtering and washing the slurry to obtain a filter cake; and
(4) drying, calcining and molding the filter cake to obtain the catalyst.

2. The preparation method according to claim 1 , wherein the total amount of silicon in the catalyst is introduced together by the silica sol and the silicon containing alkaline precipitant, and the amount of silicon introduced by the silica sol accounts for 30-70 wt %, of the total amount of silicon in the catalyst.

3. The preparation method according to claim 2 , wherein the amount of silicon introduced by the silica sol accounts for 35-65 wt % of the total amount of silicon in the catalyst; and
the silica sol is an alkaline silica sol, with a pH value of 8.0-10.0.

4. The preparation method according to claim 1 , wherein the silicon containing alkaline precipitant is a water soluble silicate;
the silicon free alkaline precipitant is selected from the group consisting of potassium carbonate, sodium bicarbonate, potassium bicarbonate, sodium hydroxide, potassium hydroxide, ammonium carbonate, ammonium bicarbonate, carbamide and ammonia water and combinations thereof.

5. The preparation method according to claim 1 , wherein the particle size of the organic pore-forming agent is less than 100 μm.

6. The preparation method according to claim 5 , wherein the particle size of the organic pore-forming agent is 1-80 μm;
the organic pore-forming agent is selected from the group consisting of PMMA, microcrystalline cellulose and methyl cellulose and combinations thereof.

7. The preparation method according to claim 1 , wherein the amount of the organic pore-forming agent accounts for 0.5-20 wt % of the total weight of the catalyst.

8. The preparation method according to claim 1 , wherein in step (1), the mass ratio of the small molecule alcohol to water is 1:20 to 1:10.

9. The preparation method according to claim 8 , wherein the small molecule alcohol in step (1) is selected from the group consisting of methanol, ethanol, propanol and butanol and combinations thereof.

10. The preparation method according to claim 1 , wherein the Gemini surfactant in the step (1) is added in an amount of 0.1%-1% of the total mass of the water and the small molecular alcohol.

11. The preparation method according to claim 10 , wherein the Gemini surfactant is a bromide having a structure of C m-n-m , wherein m is 12, 14, or 16, and n is 2, 3, 6, 8 or 10.

12. The preparation method according to claim 1 , wherein the rare-earth metal is lanthanum and/or cerium; the alkaline-earth metal is selected from the group consisting of magnesium, calcium and barium and combinations thereof.

13. The preparation method according to claim 12 , wherein the salt of the copper containing compound is selected from the group consisting of copper nitrate, copper chloride and copper acetate and combinations thereof; the salt of the zinc containing compound is selected from the group consisting of zinc nitrate, zinc chloride and zinc acetate and combinations thereof; the salt of the rare-earth metal compound is selected from the group consisting of nitrate, chloride and acetate and combinations thereof; the salt of alkaline-earth metal compound is selected from the group consisting of nitrate, chloride and acetate and combinations thereof.

14. The preparation method according to claim 1 , wherein the temperature of the reaction process and the aging process in step (2) is 60-90° C.;
in step (4), the calcining temperature is 300-700° C. and the calcining time is 4-12h.

15. The catalyst prepared by the preparation method according to claim 1 ; based on the total weight of the catalyst, the prepared catalyst contains 20-65 wt % of copper oxide, 15-50 wt % of silicon oxide, 2-25 wt % of zinc oxide, 0.1-5 wt % of rare-earth metal oxide and 0.5-15 wt % of alkaline-earth metal oxide.

16. The preparation method according to claim 15 , wherein the prepared catalyst contains 40-63 wt % of copper oxide, 20-45 wt % of silicon oxide, 5-20 wt % of zinc oxide, 0.2-3 wt % of rare-earth metal oxide and 0.5-10 wt % of alkaline-earth metal oxide.

17. The preparation method according to claim 15 , wherein the prepared catalyst contains 42-60 wt % of copper oxide, 22-40 wt % of silicon oxide, 10-18 wt % of zinc oxide, 0.5-2 wt % of rare-earth metal oxide and 1-5 wt % of alkaline-earth metal oxide.

18. A method for producing α-phenylethanol in the liquid phase hydrogenation of acetophenone, comprising contacting acetophenone with the catalyst prepared by the preparation method according to claim 1 in the presence of H 2 and recovering α-phenylethanol.

19. The method according to claim 18 , wherein before catalyzing the hydrogenation of acetophenone to produce α-phenylethanol, the catalyst is reduced and activated;
the reduction and activation of the catalyst includes the following steps: introducing a mixed gas of hydrogen and nitrogen with a volume fraction of H 2 not more than 10 v % while maintaining the volume space velocity of the mixed gas of hydrogen and nitrogen to be 300-1000 h −1 to pre-reduce the catalyst for at least 0.5 h, followed by gradually increasing the proportion of hydrogen in mixed gas of hydrogen and nitrogen and controlling the hot spot temperature of the catalyst bed in this process to not exceed 220° C., and finally raising the temperature to 200-220° C. and reducing in a pure hydrogen atmosphere for 2-5 h to obtain an activated catalyst.

20. The method according to claim 19 , wherein the contacting conditions for the hydrogenation of acetophenone to produce α-phenylethanol using the obtained activated catalyst include: a reaction pressure of 2.5-5 MPa, a reaction temperature of 70-140° C., a H 2 /ACP molar ratio of 2-20:1 and a catalyst amount of 0.2-0.6 g ACP ·g cat −1 ·h −1 .

Assignees

• Wanhua Chemical Group Co Ltd

Inventors

• Li Zuojin
• Yu Haibo
• Zhan Jishan
• Sha Yu
• Chu Naibo
• Li Yuan
• Hua Weiqi

Classifications

• B01J2523/00

  Constitutive chemical elements of heterogeneous catalysts · CPC title

• B01J37/0018 Primary

  Addition of a binding agent or of material, later completely removed among others as result of heat treatment, leaching or washing,(e.g. forming of pores; protective layer, desintegrating by heat) · CPC title

• B01J23/83 Primary

  with rare earths or actinides · CPC title

• C07C29/145

  with hydrogen or hydrogen-containing gases · CPC title

• B01J37/031

  Precipitation · CPC title