Integrated circuit design for wireless control of biphasic stimulation in bioelectronic implant

Patent metadata

Field	Value
Publication number	US-11167134-B2
Application number	US-201816208007-A
Country	US
Kind code	B2
Filing date	Dec 3, 2018
Priority date	Dec 4, 2017
Publication date	Nov 9, 2021
Grant date	Nov 9, 2021

Abstract

A system for providing biphasic stimulation is disclosed. The system includes an electrode, an antenna coupled to a transmitter, a capacitor, a power supply, a backscatter load selectively coupled to the antenna via a switching device, a plurality of switches, and a controller configured to control the switching device to output, by the antenna, an acknowledgement signal to the transmitter responsive to receiving the power. The controller is further configured to control the plurality of switches to electrically couple a first plate of the capacitor to the electrode to provide a first nerve stimulation signal having a first polarity, and electrically couple a second plate of the capacitor to the electrode to provide a second nerve stimulation signal having a second polarity opposite the first polarity. The system further includes a housing encapsulating the antenna, the capacitor, the power supply, the backscatter load, the switches, and the controller.

First claim

What is claimed is:

1. A system for providing biphasic stimulation, the system comprising:
a first electrode and a second electrode;
an antenna configured to be inductively coupled to a transmitter;
a capacitor having a first plate and a second plate;
a power supply configured to be electrically coupled to the capacitor and to the antenna, and configured to charge the capacitor;
a plurality of switches electrically coupled to the first electrode, the capacitor, and the power supply;
a controller electrically coupled to, and configured to provide control signals to, the plurality of switches to:
electrically couple, in a first mode of operation, the first plate of the capacitor to the first electrode to provide a first nerve stimulation signal having a first polarity by closing a first switch in a first conductive path between the first plate of the capacitor and the first electrode, opening a second switch in a second conductive path between the first plate of the capacitor and a reference terminal maintained at a reference potential, opening a third switch in a third conductive path between the second plate of the capacitor and the first electrode, and closing a fourth switch in a fourth conductive path between the second plate of the capacitor and the reference terminal, each of the first through fourth switches being distinct from one another; and
electrically couple, in a second mode of operation, the second plate of the capacitor to the first electrode to provide a second nerve stimulation signal having a second polarity opposite the first polarity by opening the first switch in the first conductive path between the first plate of the capacitor and the first electrode, closing the second switch in the second conductive path between the first plate of the capacitor and the reference terminal, closing the third switch in the third conductive path between the second plate of the capacitor and the first electrode, and opening the fourth switch in the fourth conductive path between the second plate of the capacitor and the reference terminal, the second electrode being maintained at the reference potential in each of the first mode of operation and the second mode of operation; and

a housing encapsulating the antenna, the capacitor, the power supply, the plurality of switches, and the controller.

2. The system of claim 1 , further comprising a receiver coupled to the antenna, the receiver configured to detect a wake-up signal from the antenna and provide the wake-up signal to the power supply to charge the power supply.

3. The system of claim 2 , wherein the controller is further configured to enable at least one of the first nerve stimulation signal and the second nerve stimulation signal responsive to determining that the wake-up signal includes a unique identifier of the system.

4. The system of claim 1 , wherein the housing is dimensioned to be smaller than or equal to 1 mm 3 .

5. The system of claim 1 , wherein the system is configured to provide biphasic stimulation with a net current density of 50 μA/mm 2 .

6. The system of claim 1 , wherein the capacitor, the plurality of switches, and the controller are contained within an application-specific integrated circuit (ASIC).

7. The system of claim 6 , wherein the ASIC has a dimension of 300 μm or less.

8. The system of claim 6 , wherein the ASIC is configured to operate on 500 mV or less.

9. The system of claim 1 , wherein the power supply comprises a storage capacitor.

10. The system of claim 1 , wherein the first nerve stimulation signal and the second nerve stimulation signal have different magnitudes.

11. The system of claim 1 , wherein the housing is constructed from biocompatible materials.

12. The system of claim 11 , wherein the housing is hermetically sealed.

13. The system of claim 1 , further comprising a voltage regulator coupled to the power supply, the voltage regulator being configured to provide electrical power to the power supply to charge the power supply.

14. The system of claim 13 , wherein the voltage regulator is operable with a supply voltage of 300 mV.

15. The system of claim 14 , wherein the voltage regulator includes a second plurality of switches, and wherein each switch of the second plurality of switches is configured to operate in a subthreshold region.

16. The system of claim 1 , further comprising a backscatter load selectively coupled to the antenna via a switching device, the controller being electrically coupled to, and configured to provide first control signals to, the switching device to selectively couple the backscatter load to the antenna to output, by the antenna, an acknowledgement signal to the transmitter responsive to receiving the power, and to control the switching device to switchably connect the backscatter load to the antenna to output, by the antenna, one or more commands to the transmitter.

17. The system of claim 16 , wherein the controller being configured to control the switching device includes controlling the switching device to switchably connect the backscatter load to the antenna to modulate a load coupled to the antenna.

18. A method of providing biphasic stimulation by an implantable biphasic nerve stimulation device including a capacitor, a first electrode, a second electrode, and a power supply, the method comprising:
receiving, by the implantable biphasic nerve stimulation device, power from an external power source;
electrically coupling, in a first mode of operation, the capacitor to the power supply;
in a second mode of operation, electrically coupling a first plate of the capacitor to the first electrode and electrically coupling a second plate the capacitor to a reference node maintained at a reference potential by closing a first switch in a first conductive path between the first plate of the capacitor and the first electrode, opening a second switch in a second conductive path between the first plate of the capacitor and the reference node, opening a third switch in a third conductive path between the second plate of the capacitor and the first electrode, and closing a fourth switch in a fourth conductive path between the second plate of the capacitor and the reference node, each of the first through fourth switches being distinct from one another;
providing, by the first plate of the capacitor, a first nerve stimulation signal having a first polarity to the first electrode in the second mode of operation;
in a third mode of operation, electrically coupling the first plate of the capacitor to the reference node and electrically coupling the second pate of the capacitor to the first electrode by opening the first switch in the first conductive path between the first plate of the capacitor and the first electrode, closing the second switch in the second conductive path between the first plate of the capacitor and the reference node, closing the third switch in the third conductive path between the second plate of the capacitor and the first electrode, and opening the fourth switch in the fourth conductive path between the second plate of the capacitor and the reference node;
providing, by the second plate of the capacitor, a second nerve stimulation signal having a second polarity to the first electrode in the third mode of operation, the second polarity being opposite the first polarity, the second electrode being maintained at the reference potential in both the second mode of operation and the third mode of operation; and
communicating, by the implantable biphasic nerve stimulation device, an acknowledgement signal to the ex

Assignees

• Charles Stark Draper Laboratory Inc

Inventors

• Guyon Daniel J
• Freeman Daniel K
• Wheeler Jesse J

Classifications

• A61N1/37288 Primary

  Communication to several implantable medical devices within one patient · CPC title

• A61N1/36125

  Details of circuitry or electric components · CPC title

• A61N1/37223

  Circuits for electromagnetic coupling · CPC title

• A61N1/36142

  for improving safety · CPC title

• A61N1/3787

  from an external energy source · CPC title