Process for producing organic compound

Patent metadata

Field	Value
Publication number	US-11161820-B2
Application number	US-202016810050-A
Country	US
Kind code	B2
Filing date	Mar 5, 2020
Priority date	Sep 8, 2017
Publication date	Nov 2, 2021
Grant date	Nov 2, 2021

Abstract

A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.

First claim

What is claimed is:

1. A process for producing an organic compound using an apparatus comprising:
a first flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are introduced from separate feeding channels, mixed in a first mixing unit, and then reacted in a first reactor unit, and
a second flow reactor for a second reaction in which a first reaction solution discharged from the first flow reactor for the first reaction and a raw material liquid C are introduced from separate feeding channels, mixed in a second mixing unit, and then reacted in a second reactor unit,
wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved,
wherein the raw material liquid B is a nitrogen-containing organic compound not including an amino group, an amino group comprising one substituent on N, an amido group, an amido group comprising one substituent on N, a —OC(═O)NH 2 , and a —OC(═O)NH 2 comprising one substituent on N, or a solution of the nitrogen-containing organic compound,
wherein the raw material liquid C is a reaction substrate having at least one functional group capable of reacting with phosgene, the functional group being selected from the group consisting of an amino group, an amino group comprising one substituent on N, an amido group, an amido group comprising one substituent on N, a —OC(═O)NH 2 , and a —OC(═O)NH 2 comprising one substituent on N, or a solution containing the reaction substrate, and
wherein a product of the first reaction is phosgene.

2. The process according to claim 1 ,
wherein the organic compound produced is a compound having at least one functional group selected from the group consisting of a chlorocarbonylated amino group, a chlorocarbonylated amino group comprising one substituent on N, a chlorocarbonylated amide group, a chlorocarbonylated amide group comprising one substituent on N, a chlorocarbonylated —OC(═O)NH 2 , and a chlorocarbonylated —OC(═O)NH 2 group comprising one substituent on N, a compound having a structure of N-carboxyanhydride, or a compound having a isocyanate or urea structure.

3. The process according to claim 1 ,
wherein the nitrogen-containing organic compound not including an amino group, an amino group comprising one substituent on N, an amido group, an amido group comprising one substituent on N, a —OC(═O)NH 2 , and a —OC(═O)NH 2 comprising one substituent on N is a trialkylamine having 9 to 40 carbon atoms, and
wherein the solution in which triphosgene and/or diphosgene is dissolved contains an organic solvent.

4. The process according to claim 1 ,
wherein a flow channel to discharge the first reaction solution from the first reactor unit of the first flow reactor for the first reaction is directly connected to the mixing unit of the second flow reactor for the second reaction.

5. The process according to claim 1 ,
wherein the first reactor unit has a cross-sectional area of 0.15 mm 2 to 30 cm 2 .

6. The process according to claim 1 ,
wherein the second reactor unit has a cross-sectional area of 0.15 mm 2 to 30 cm 2 .

Assignees

• Kaneka Corp

Inventors

• Yasukouchi Hiroaki
• Nishiyama Akira
• Machida Koji

Classifications

• C07D217/06 Primary

  with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates · CPC title

• C01B32/80

  Phosgene · CPC title

• B01J19/1812

  Tubular reactors · CPC title

• B01J19/0053

  Details of the reactor · CPC title

• B01J19/0093 Primary

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title