Method for manufacturing transdermal absorption sheet

Patent metadata

Field	Value
Publication number	US-11160965-B2
Application number	US-202117202360-A
Country	US
Kind code	B2
Filing date	Mar 16, 2021
Priority date	Sep 26, 2018
Publication date	Nov 2, 2021
Grant date	Nov 2, 2021

Abstract

Provided is a method for manufacturing a transdermal absorption sheet which makes it possible to manufacture a transdermal absorption sheet with a stable shape. The method for manufacturing a transdermal absorption sheet includes a step of forming a drug layer (110) on needle-like recess portions (42) of a mold (50) having the needle-like recess portions (42), a step of supplying a polymer layer forming solution (112) to the inside of a step portion (52) of the mold (50), a step of drying the polymer layer forming solution (112) so as to form a polymer layer (114) and a transdermal absorption sheet (120), and a step of peeling off the transdermal absorption sheet (120) from the mold (50). In the step of peeling off, pressing force is applied to a part of the step portion (52) in a second direction (B) opposite to a first direction (A) in which the transdermal absorption sheet (120) is released from the mold (50), and the transdermal absorption sheet (120) is aspirated with a vacuum suction pad (160) from a side opposite to the mold (50) so that the transdermal absorption sheet (120) is peeled off from the mold (50) in the first direction (A).

First claim

What is claimed is:

1. A method for manufacturing a transdermal absorption sheet, comprising:
a step of filling needle-like recess portions of a mold with a drug solution and drying the drug solution so as to form a drug layer, wherein the mold includes the needle-like recess portions and a step portion that is formed around a region where the needle-like recess portions are formed, and an upper surface of the step portion is higher than an upper surface of the region where the needle-like recess portions are formed;
a step of supplying a polymer layer forming solution to an inside of the step portion;
a step of drying the polymer layer forming solution so as to form a polymer layer and a transdermal absorption sheet; and
a step of peeling off the transdermal absorption sheet from the mold,
wherein in the step of peeling off, pressing force is applied to a part of the step portion in a second direction opposite to a first direction in which the transdermal absorption sheet is released from the mold, and the transdermal absorption sheet is aspirated by a vacuum suction pad from a side opposite to the mold so that the transdermal absorption sheet is peeled off from the mold in the first direction, and
wherein the pressing force is applied using a pressing jig, and
in an entire circumference of the step portion of the mold, a proportion of the part to which the pressing force is applied is equal to or lower than 75%.

2. The method for manufacturing a transdermal absorption sheet according to claim 1 ,
wherein the vacuum suction pad is a flat pad.

3. The method for manufacturing a transdermal absorption sheet according to claim 1 ,
wherein the pressing force is applied to the step portion at equal intervals.

4. The method for manufacturing a transdermal absorption sheet according to claim 1 ,
wherein in a case where a point of contact between the step portion and a wall portion extending to the step portion from the region where the needle-like recess portions are formed is regarded as a contact position, in the step of supplying the polymer layer forming solution, the polymer layer forming solution is supplied so that the solution flows over the contact position from the region where the needle-like recess portions are formed and is then fixed to the contact position while being contracted.

5. The method for manufacturing a transdermal absorption sheet according to claim 1 ,
wherein the first direction is a direction perpendicular to the region where the needle-like recess portions are formed.

6. The method for manufacturing a transdermal absorption sheet according to claim 1 ,
wherein an aspiration force of the vacuum suction pad is equal to or higher than 50 kPa and equal to or lower than 60 kPa.

7. The method for manufacturing a transdermal absorption sheet according to claim 1 ,
wherein the pressing force is applied using the pressing jig including a tubular base portion and claw portions connected to the base portion by bringing the claw portions into contact with the step portion.

Assignees

• Fujifilm Corp

Inventors

• Tamaki Kenichiro

Classifications

• B29C37/0007

  using means operable from outside the mould for moving between mould parts, e.g. robots · CPC title

• B29C2059/023

  Microembossing · CPC title

• B29C43/36

  Moulds for making articles of definite length, i.e. discrete articles · CPC title

• B29K2995/0056

  Biocompatible, e.g. biopolymers or bioelastomers · CPC title

• B29L2031/757

  Moulds, cores, dies · CPC title