Medical device packaging and related methods

Patent metadata

Field	Value
Publication number	US-11160918-B2
Application number	US-202016942271-A
Country	US
Kind code	B2
Filing date	Jul 29, 2020
Priority date	Jul 29, 2019
Publication date	Nov 2, 2021
Grant date	Nov 2, 2021

Abstract

According to one aspect of the disclosure, packaging for a sterile syringe having a nominal size of less than 1 mL may include a flexible tray having a cavity for containing the syringe. The cavity may include an opening, one or more sidewalls, and a base. A lip may surround the opening, may extend radially outward from the cavity, and may define a periphery of the tray. A removable cover may have a periphery that is adhered to the lip, and the removable cover may be permeable to a gaseous sterilant, including one or more of vaporized hydrogen peroxide or ethylene oxide. A projection may be associated with the base of the cavity and may extend away from the base of the cavity in a direction opposite to the opening of the cavity.

First claim

What is claimed is:

1. A packaging comprising:
a tray having an opening, a cavity including three cavity portions, a plurality of sidewalls, and a base;
a sterile syringe contained within the cavity, wherein the sterile syringe is pre-filled with a medicament;
wherein a first cavity portion comprises a plunger of the sterile syringe, a second cavity portion comprises a barrel of the sterile syringe, and a third cavity portion comprises a needle attachment portion of the sterile syringe, wherein the three cavity portions are connected to one another by intermediate narrowed portions,
the narrowed portions including a plurality of geometric features projecting into the narrowed portions to position the sterile syringe away from the plurality of sidewalls, and
wherein the sterile syringe extends through the narrowed portions,

a removable cover sealing the opening, wherein the removable cover is permeable to a gaseous sterilant configured to maintain a sterile barrier, and
a projection associated with the tray at a location in line with a portion of the sterile syringe;
wherein, in a first state, the projection extends away from the sterile syringe in a direction opposite from the opening of the cavity;
wherein the projection is configured to transition from the first state to a second state when subjected to pressure; and
wherein, in the second state, the projection is inverted so that a portion of the projection extends towards the portion of the sterile syringe in line with the projection.

2. The packaging of claim 1 , wherein the projection is located in line with a barrel of the sterile syringe when in the first state.

3. The packaging of claim 1 , wherein the medicament is one of aflibercept, ranibizumab, bevacizumab, conbercept, OPT-302, RTH258 (brolocizumab), a pegylated designed ankyrin repeating protein (DARPin), or RG7716.

4. The packaging of claim 1 , wherein the projection is dome-shaped, and wherein a diameter of the base of the dome-shaped projection is approximately 10 mm to 20 mm.

5. The packaging of claim 1 , wherein the three cavity portions are arranged in series along a longitudinal axis of the tray.

6. The packaging of claim 5 , wherein the second cavity portion is located between the first cavity portion and the third cavity portion.

7. The packaging of claim 1 , wherein the tray is formed from a suitable thermoplastic material, including one or more of polypropylene, polystyrene, polyethylene, polycarbonate, polyvinyl chloride, or polyethylene terephthalate glycol.

8. The packaging of claim 1 , wherein a depth of the projection from an apex of the projection to a base of the projection is approximately 5 mm to 6 mm, and a distance between the base of the projection and a portion of the syringe overlying the projection is approximately 3 mm to 4 mm.

Assignees

• Regeneron Pharma
• Regeneran Pharmaceuticals Inc

Inventors

• Cook Andrew
• Bradford Victor

Classifications

• B65D75/36

  one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages {, the recess or recesses being preformed (B65D73/0057, B65D73/0092 take precedence)} · CPC title

• B65D85/70

  for materials not otherwise provided for · CPC title

• B65D83/00

  Containers or packages with special means for dispensing contents (dispensing means incorporated in closures B65D47/00) · CPC title

• B65D75/5855

  Peelable seals · CPC title

• B65B69/005

  by expelling contents, e.g. by squeezing the container · CPC title