Method, apparatus, and computer program product for controlling components of a detection device

Patent metadata

Field	Value
Publication number	US-11148144-B2
Application number	US-201815958722-A
Country	US
Kind code	B2
Filing date	Apr 20, 2018
Priority date	Apr 20, 2017
Publication date	Oct 19, 2021
Grant date	Oct 19, 2021

Abstract

A method, computer program product, and apparatus are provided for controlling components of a detection device. The device may detect turbidity of liquid with sensors such as a density sensor and/or nephelometric sensor. A light modulation pattern may reduce or eliminate interference in sensor readings. Readings may be performed during off cycles of an illumination light to reduce interference but to provide improved visibility of a tube. Dark and light sensor readings may be performed with an emitter respectively off or on to account for ambient light in subsequent readings. Readings from the density sensor and/or nephelometric sensor may be used to calculate McFarland values. The device may be zeroed based on an emitter level that results in a sensor reading satisfying a predetermined criterion.

First claim

The invention claimed is:

1. A method for operating an optical testing instrument to reduce light interference from an illumination light in sensor readings, the method comprising:
causing an illumination light to be powered on and off according to a light modulation pattern, wherein the illumination light is configured to emit light that is visible to a user outside the optical testing instrument, wherein the illumination light provides improved visibility of contents of a sample tube observable by the user during a testing of the contents, and wherein the light modulation pattern comprises a plurality of on cycles and a plurality of off cycles including a first off cycle, the first off cycle of the light modulation pattern being between adjacent on cycles of the plurality of on cycles;
during the first off cycle of the light modulation pattern, controlling at least one emitter to emit a signal for detection by one or more sensors;
controlling at least one of the one or more sensors to perform a sensor reading during the first off cycle of the light modulation pattern, wherein the first off cycle defines a sufficiently short duration to cause the adjacent on cycles to appear substantially constant to the user during operation of the at least one of the one or more sensors during the first off cycle; and
causing the one or more sensors to not perform sensor readings during the plurality of on cycles of the light modulation pattern.

2. The method of claim 1 , further comprising:
controlling the at least one of the one or more sensors to perform a dark reading while the at least one emitter is off;
determining an ambient light offset by subtracting the dark reading from a light reading; and
calibrating sensor readings according to the ambient light offset.

3. The method of claim 1 , further comprising:
controlling the at least one of the one or more sensors to perform a plurality of readings over the plurality of off cycles in the light modulation pattern; and
calculating a moving average sensor reading based on the plurality of readings.

4. The method of claim 1 , further comprising:
controlling sensor readings to begin after a predetermined delay after a start of a respective off cycle of the light modulation pattern.

5. The method of claim 1 , further comprising:
receiving an indication of a tube insertion; and
controlling sensor reading cycles to begin after a predetermined initial delay after the receipt of the indication of the tube insertion.

6. The method of claim 1 , wherein the at least one of the one or more sensors comprises at least one density sensor and at least one nephelometric sensor, the method further comprising determining a McFarland value by:
receiving a plurality of density sensor readings;
receiving a plurality of nephelometric sensor readings;
applying linear regression to the density sensor readings to determine a first coefficient of a polynomial equation;
applying linear regression to the nephelometric sensor readings to determine a second coefficient of the polynomial equation; and

applying subsequent readings to the polynomial equation to calculate the McFarland value.

7. The method of claim 6 , further comprising:
detecting an error in at least one of the one or more sensors based on a comparison of the density sensor readings and the nephelometric sensor readings.

8. The method of claim 1 , further comprising zeroing a detection device, the method comprising:
receiving an indication to perform a zeroing calibration;
in response to the indication of the zeroing calibration, controlling the at least one emitter to adjust an emitted signal;
controlling the at least one of the one or more sensors to perform readings based on the emitted signal;
monitoring the readings and storing a level of the emitted signal when at least one reading satisfies a predetermined criterion; and
controlling the at least one emitter to operate based on the stored level of the emitted signal.

9. The method of claim 1 , wherein the light modulation pattern comprises powering on the illumination light during an on cycle to illuminate the contents of the sample tube and emitting a source light with the emitter during an off cycle at different times.

10. The method of claim 1 , wherein the first off cycle defines a duration less than 21 ms.

11. The method of claim 1 , wherein the duration of the first off cycle is at least a time required to process the sensor readings of the at least one of the one or more sensors.

12. The method of claim 1 further comprising controlling the at least one of the one or more sensors to perform readings after a predetermined number of off cycles, such that an interval between each reading is a multiple of a duty cycle and an off cycle duration.

13. An apparatus for reducing light interference from an illumination light in sensor readings, the apparatus comprising processing circuitry configured to cause the apparatus to:
cause an illumination light to be powered on and off according to a light modulation pattern, wherein the illumination light is configured to emit light that is visible to a user outside the apparatus, wherein the illumination light provides improved visibility of contents of a sample tube observable by the user during a testing of the contents, and wherein the light modulation pattern comprises a plurality of on cycles and a plurality of off cycles including a first off cycle, the first off cycle of the light modulation pattern being between adjacent on cycles of the plurality of on cycles;
during the first off cycle of the light modulation pattern, control at least one emitter to emit a signal for detection by one or more sensors;
control at least one of the one or more sensors to perform a sensor reading during the first off cycle of the light modulation pattern, wherein the first off cycle defines a sufficiently short duration to cause the adjacent on cycles to appear substantially constant to the user during operation of the at least one of the one or more sensors during the first off cycle; and
causing the one or more sensors to not perform sensor readings during the plurality of on cycles of the light modulation pattern.

14. The apparatus of claim 13 , wherein the processing circuitry is further configured to cause the apparatus to:
control the at least one of the one or more sensors to perform a dark reading while the at least one emitter is off;
determine an ambient light offset by subtracting the dark reading from a light reading; and
calibrate sensor readings according to the ambient light offset.

15. The apparatus of claim 13 , wherein the processing circuitry is further configured to cause the apparatus to:
control the at least one of the one or more sensors to perform a plurality of readings over a plurality of off cycles in the light modulation pattern; and
calculate a moving average sensor reading based on the plurality of readings.

16. The apparatus of claim 13 , wherein the processing circuitry is further configured to cause the apparatus to:
control sensor readings to begin after a predetermined delay after a start of a respective off cycle of the light modulation pattern.

17. The apparatus of claim 13 , wherein the processing circuitry is further configured to cause the apparatus to:
receiving an indication of a tube insertion; and
controlling sensor reading cycles to begin after a predetermined initial delay after the receipt of the indication of the tube insertion.

18. The apparatus of claim 13 , wherein the at least one of the one

Assignees

• Bio Merieux Inc

Inventors

• Harrison Joel Patrick
• Korte John Kenneth
• Price Jeffrey Edward

Classifications

• G01N21/8806

  Specially adapted optical and illumination features · CPC title

• B01L2300/0803

  Disc shape · CPC title

• G01N21/474

  Details of optical heads therefor, e.g. using optical fibres · CPC title

• G01N33/48735

  Investigating suspensions of cells, e.g. measuring microbe concentration (by chemical means C12Q1/04; colony counters C12M1/34; concentration of particle suspensions in general G01N15/06) · CPC title

• G01N21/5907

  Densitometers · CPC title