Gas-filled stabilized particles and methods of use
US-10577554-B2 · Mar 3, 2020 · US
Stimuli-responsive particles encapsulating a gas and methods of use
US11147890B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11147890-B2 |
| Application number | US-201816489541-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 28, 2018 |
| Priority date | Feb 28, 2017 |
| Publication date | Oct 19, 2021 |
| Grant date | Oct 19, 2021 |
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- Title
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- Abstract
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Abstract
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Provided herein are various gas-filled particles having a stimuli-responsive shell encapsulating the gas. The stimuli-responsive shell comprises one or more release triggers. Compositions for medical or non-medical applications, methods of use and treatment, and methods of preparation are also described.
First claim
Opening claim text (preview).
We claim: 1. A composition comprising a stable particle having a shell surrounding a gas core, wherein the shell includes a release trigger, wherein the release trigger is a pH-responsive trigger, wherein the shell comprises succinylated and acetylated dextran (Dex-Ac-Suc), and wherein the succinyl moiety of the Dex-Ac-Suc is the pH-responsive trigger. 2. The composition of claim 1 , wherein the shell comprises nanoparticle aggregates. 3. The composition of claim 2 , wherein the stable particle is formed by nanoprecipitation of an amphiphilic polymer comprising the release trigger at an air/liquid interface to form the shell. 4. The composition of claim 3 , wherein the amphiphilic polymer comprises acetylated dextran (Dex-Ac). 5. The composition of claim 2 , wherein the nanoparticle aggregates comprise primary particles, each primary particle having an average diameter of 50 nm or less, and wherein the shell has a thickness of 10-280 nm. 6. The composition of claim 1 , wherein the stable particle is formed by nanoprecipitation of an amphiphilic polymer comprising the release trigger at an air/liquid interface to form the shell.
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Classifications
Medicinal preparations containing inorganic active ingredients · CPC title
Drugs for disorders of the blood or the extracellular fluid · CPC title
Solutions {(composition of solutions A61K47/00)} · CPC title
Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin · CPC title
- A61K49/223Primary
Microbubbles, hollow microspheres, free gas bubbles, gas microspheres · CPC title
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Frequently asked questions
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- What does patent US11147890B2 cover?
- Provided herein are various gas-filled particles having a stimuli-responsive shell encapsulating the gas. The stimuli-responsive shell comprises one or more release triggers. Compositions for medical or non-medical applications, methods of use and treatment, and methods of preparation are also described.
- Who is the assignee on this patent?
- Childrens Medical Center
- What technology area does this patent fall under?
- Primary CPC classification A61K49/223. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).