Optical density instrument and systems and methods using the same

Patent metadata

Field	Value
Publication number	US-11141733-B2
Application number	US-201916655315-A
Country	US
Kind code	B2
Filing date	Oct 17, 2019
Priority date	Apr 20, 2017
Publication date	Oct 12, 2021
Grant date	Oct 12, 2021

Abstract

Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

First claim

The invention claimed is:

1. An optical density testing apparatus, the apparatus comprising:
a housing defining an opening and a cavity, wherein the housing is configured to receive at least a portion of a sample tube in the cavity via the opening, and wherein the opening is configured to allow a user to view contents of the sample tube during testing;
an emitter disposed in the housing, wherein the emitter is configured to emit light towards the sample tube;
at least one sensor disposed in the housing and configured to receive the emitted light from the emitter and generate a signal indicative of an intensity of the received light;
an illumination light disposed in the cavity and configured to illuminate the sample tube to allow the user to view contents of the sample tube during testing; and
a spring configured to engage the sample tube in an operational position, the spring defining a first leg and a second leg, wherein the first leg and the second leg are configured to apply a force on the sample tube towards a point between the first leg and the second leg.

2. The apparatus of claim 1 , wherein the housing is configured to allow access to the sample tube during testing such that a user may add or remove contents from the sample tube during testing.

3. The apparatus of claim 1 , wherein the illumination light is oriented at least partially towards the opening.

4. The apparatus of claim 1 , further comprising a window disposed in the housing between the illumination light and a position at which the sample tube is configured to be disposed during testing, such that the illumination light is configured to illuminate the sample tube via the window.

5. The apparatus of claim 1 , further comprising an optical test platform integral with or attached to the housing, wherein the optical test platform is configured to support the sample tube during testing.

6. The apparatus of claim 5 , wherein the optical test platform defines a lower end opposite the opening of the housing, and wherein the lower end comprises a window embedded in a shell of the optical test platform.

7. The apparatus of claim 1 , wherein the emitter and the illumination light are configured to operate at different frequencies.

8. The apparatus of claim 1 , wherein the at least one sensor comprises at least two sensors including a density sensor and a nephelometric sensor, the density sensor being positioned opposite the emitter relative to the cavity and configured detect the emitted light transmitted through a sample contained in the sample tube, and the nephelometric sensor being positioned perpendicular to an axis spanning the density sensor and the emitter and configured to detect the emitted light reflected by a sample in the sample tube.

9. The apparatus of claim 1 , further comprising processing circuitry configured to:
control operation of at least the emitter, the illumination light, and the at least one sensor;
convert raw light data from the at least one sensor into optical density data; and
cause transmission of the optical density data to a display screen in real time.

10. The apparatus of claim 1 further comprising a wireless transmitter configured to wirelessly transmit optical density data from the apparatus to a receiving device.

11. The apparatus of claim 9 , further comprising a plurality of ribs defined in the cavity of the housing.

12. The apparatus of claim 9 , further comprising a guide surface of a window embedded in a wall of the housing.

13. The apparatus of claim 9 , further comprising:
a plurality of ribs defined in the cavity of the housing; and
a guide surface of a window embedded in a wall of the housing.

14. The apparatus of claim 1 , wherein the emitter and the illumination light are configured operate according to a light modulation pattern.

15. The apparatus of claim 14 , wherein the light modulation pattern defines an off state of the illumination light during at least one instance of the at least one sensor receiving the emitted light from the emitter.

16. The apparatus of claim 1 , wherein the apparatus is a hand-held device.

17. An optical density testing system, the system comprising:
a sample tube; and
an apparatus comprising:
a housing defining an opening and a cavity, wherein the housing is configured to receive at least a portion of the sample tube in the cavity via the opening, and wherein the opening is configured to allow a user to view contents of the sample tube during testing;
an emitter disposed in the housing, wherein the emitter is configured to emit light towards the sample tube;
at least one sensor disposed in the housing and configured to receive the emitted light from the emitter and generate a signal indicative of an intensity of the received light;
an illumination light disposed in the cavity and configured to illuminate the sample tube to allow the user to view contents of the sample tube during testing; and
a spring configured to engage the sample tube in an operational position, the spring defining a first leg and a second leg, wherein the first leg and the second leg are configured to apply a force on the sample tube towards a point between the first leg and the second leg.

18. The system of claim 17 , wherein the sample tube comprises an open end configured to be accessible to the user in an instance in which the sample tube is inserted into the cavity.

19. The system of claim 17 , wherein the sample tube comprises a calibration tag, and wherein the apparatus comprises a processor and wireless device configured to detect the calibration tag.

20. The system of claim 17 further comprising a base station configured to operably engage the apparatus, wherein the apparatus is configured to transmit the signal indicative of an intensity of the received light to the base station, and wherein the base station comprises a screen configured to display graphical representations associated with the signal.

21. The system of claim 20 , wherein the apparatus comprises a wireless transmitter and the base station comprises a wireless receiver, such that the apparatus is configured to transmit the signal to the base station wirelessly.

22. The system of claim 21 , wherein the base station is configured to display continuous sensor data in real time during testing.

23. The system of claim 17 , further comprising a plurality of ribs defined in the cavity of the housing.

24. The system of claim 17 , further comprising a guide surface of a window embedded in a wall of the housing.

25. The system of claim 17 , further comprising:
a plurality of ribs defined in the cavity of the housing; and
a guide surface of a window embedded in a wall of the housing.

Assignees

• Bio Merieux Inc

Inventors

• Stamm Perry D
• Harrison Joel Patrick
• Maes Gregory R
• Price Jeffrey Edward
• Hoffmann Jr Jack R
• Korte John Kenneth
• Pingel Daniel Joseph
• Clynes Walter J
• Furman Sean Gregory
• Schleicher Leonard H
• Kocher Christopher George
• Peterson Brian David
• Yam Jacky S

Classifications

• G01N15/06

  Investigating concentration of particle suspensions (by weighing G01N5/00; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) · CPC title

• G01N1/10

  in the liquid or fluent state {(burettes, pipettes B01L3/02; sampling of ground water E02D1/06; metering by volume of fluids or fluent solid material G01F11/00, G01F13/00)} · CPC title

• B01L2300/0803

  Disc shape · CPC title

• G01N2021/0168

  for the measurement cycle · CPC title

• G01N21/51

  inside a container, e.g. in an ampoule (G01N21/53 takes precedence) · CPC title