Fluid path impedance assessment for improving fluid delivery performance

Patent metadata

Field	Value
Publication number	US-11141535-B2
Application number	US-201816621822-A
Country	US
Kind code	B2
Filing date	Aug 28, 2018
Priority date	Aug 31, 2017
Publication date	Oct 12, 2021
Grant date	Oct 12, 2021

Abstract

A fluid injector system for delivering a multi-phase fluid injection to a patient and methods of fluid delivery is disclosed. Methods of creating and using a multi-aspect fluid path impedance model of the injector system are used. Modeling and adjustment of factors that affect impedance and prevent or reduce backflow, reduce the likelihood of fluid flow rate spikes and provide more accurate flow rates and mixing ratios of fluids may be repeated or happen essentially continuously during an injection. The adjustments may be determined before the injection or determined and/or adjusted during the injection. The determination may include sensor feedback commonly used in injectors such as pressure and position feedback as well as other sensors. In all cases, the user can be notified of adjustments through on-screen notices and/or through the recordation of the injection data by a control device of the injector at the conclusion of the injection.

First claim

What is claimed is:

1. A method of improving fluid delivery performance of a fluid injection system, the method comprising:
prior to initiating delivery of one or more fluids, modeling one or more factors that affects impedance of the fluid injection system based upon one or more known, estimated or measured parameters, wherein the modeling is based on an adjustable model for predicting future performance of the fluid injector system;
initiating delivery of at least a first fluid of the one or more fluids to a patient at a first flow rate;
measuring one or more characteristics of the fluid delivery;
modeling one or more factors that affects impedance of the fluid injection system based upon one or more measurements of the one or more characteristics of the fluid delivery; and
adjusting one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery to improve fluid delivery performance.

2. The method of claim 1 , further comprising initiating delivery of at least a second fluid to the patient at a second flow rate.

3. The method of claim 1 , wherein an operator of the fluid injection system is notified of at least one adjustment made or suggested by the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery.

4. The method of claim 1 , further comprising adjusting the one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters prior to delivery of fluid to the patient.

5. A method of improving fluid delivery performance of a fluid injection system, the method comprising:
prior to initiating delivery of one or more fluids, modeling one or more factors that affects impedance of the fluid injection system based upon one or more known, estimated or measured parameters, wherein the modeling is based on an adjustable model for predicting future performance of the fluid injector system;
initiating delivery of at least a first fluid of the one or more fluids to a patient at a first flow rate;
measuring one or more characteristics of the fluid delivery;
modeling one or more factors that affects impedance of the fluid injection system based upon one or more measurements of the one or more characteristics of the fluid delivery; and
adjusting, during delivery of the first fluid, one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery to improve fluid delivery performance.

6. The method of claim 5 , further comprising initiating delivery of at least a second fluid to the patient at a second flow rate and adjusting the one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery during delivery of one of the first or second fluid to improve fluid delivery performance.

7. The method of claim 1 , wherein the one or more parameters is temperature, viscosity, pressure, bulk modulus, concentration, catheter size, hydraulic resistance, desired flow rate, and system capacitance.

8. The method of claim 1 , wherein the one or more characteristics of the fluid delivery is temperature, viscosity, pressure, bulk modulus, hydraulic resistance, actual flow rate, and system capacitance.

9. The method of claim 6 , wherein the adjustment of the one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery occurs during delivery of both the first and second fluids.

10. A method of improving fluid delivery performance of a fluid injection system, the method comprising:
prior to initiating delivery of one or more fluids, modeling one or more factors that affects impedance of the fluid injection system based upon one or more known, estimated or measured parameters, wherein the modeling is based on an adjustable model for predicting future performance of the fluid injector system;
initiating delivery of at least a first fluid of the one or more fluids to a patient at a first flow rate;
measuring one or more characteristics of the fluid delivery;
modeling one or more factors that affects impedance of the fluid injection system based upon the one or more measurements of the one or more characteristics of the fluid delivery;
adjusting, during delivery of the first fluid, one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery;
re-measuring one or more characteristics of the fluid delivery;
re-modeling one or more factors that affects impedance of the fluid injection system based upon one or more known, estimated or measured parameters or one or more re-measurements of the one or more characteristics of the fluid delivery; and
re-adjusting, during delivery of the first fluid, the one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system remodeled on the one or more known, estimated or measured parameters or re-modeled on the one or more re-measurements of the one or more characteristics of the fluid delivery to improve fluid delivery performance.

11. A method of improving fluid delivery performance of a fluid injection system, the method comprising:
prior to initiating delivery of one or more fluids, modeling one or more factors that affects impedance of the fluid injection system based upon one or more known, estimated or measured parameters, wherein the modeling is based on an adjustable model for predicting future performance of the fluid injector system;
initiating delivery of at least a first fluid of the one or more fluids to a patient at a first flow rate during a first phase of an injection with a first pressure limit;
measuring one or more characteristics of the fluid delivery;
modeling one or more factors that affects impedance of the fluid injection system based upon the one or more measurements of the one or more characteristics of the fluid delivery;
adjusting one or more characteristics of the fluid injection system based upon the one or more factors that affects impedance of the fluid injection system modeled on the one or more known, estimated or measured parameters or modeled on the one or more measurements of the one or more characteristics of the fluid delivery;
initiating delivery of at least a second fluid to the patient at a second flow rate and during a subsequent phase of an injection with a second pressure limit;
re-measuring one or more

Assignees

• Bayer Healthcare Llc

Inventors

• Uber Iii Arthur
• Marsh Chelsea
• Barone William
• Mcdermott Michael
• Newing Timothy
• Spohn Michael
• Delbrugge Vince
• Schriver Ralph
• Cowan Kevin
• Tucker Barry
• Heller Ronald
• Griffiths David
• Schrauder Matthew

Classifications

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61M2205/3341

  stabilising pressure or flow to avoid excessive variation · CPC title

• A61M5/007

  for contrast media · CPC title

• A61B6/58

  Testing, adjusting or calibrating thereof · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title