HD acid concentrate with amino acids

Patent metadata

Field	Value
Publication number	US-11141395-B2
Application number	US-201716317832-A
Country	US
Kind code	B2
Filing date	Jul 21, 2017
Priority date	Jul 22, 2016
Publication date	Oct 12, 2021
Grant date	Oct 12, 2021

Abstract

A precursor composition for the preparation of a dialysis fluid, the precursor composition comprising at least a glucose component, an acid component, and an amino acid component, wherein the amino acid component comprises Valine, Isoleucine and Leucine.

First claim

The invention claimed is:

1. A dialysis fluid precursor composition for the preparation of a dialysis fluid, the precursor composition comprising at least a glucose component, an acid component, and an amino acid component, wherein
the amino acid component comprises Valine, Isoleucine and Leucine, and the amino acid component is free from Methionine or Tryptophan or that the amino acid component is free from Methionine and Tryptophan.

2. The precursor composition according to claim 1 , characterized in that the precursor composition further comprises sodium chloride.

3. The precursor composition according to claim 1 , which is in the form of a dry form, or a liquid concentrate.

4. The precursor composition according to claim 2 , characterized in that the precursor composition further comprises at least one cation selected from potassium, calcium and magnesium and an acid component selected from citric acid, acetic acid, hydrochloric acid and succinic acid.

5. The precursor composition according to claim 1 , characterized in that the acid amino acid component comprises Leucine, Isoleucine, Valine, and at least one of Phenylalanine, Lysine, Threonine and Histidine, or comprises all of the aforementioned amino acids, or consists of Leucine, Isoleucine, Valine, Phenylalanine, Lysine, Threonine and Histidine.

6. The precursor composition according to claim 1 , characterized in that the amino acid component consists of Valine, Leucine and Isoleucine, or the precursor composition is characterized in that the amino acid component consists of Valine, Leucine and Isoleucine, and is present in an amount to yield upon mixing with a diluent in a dialysis fluid the respective amino acid concentration ranges of

Amio Acid
Concentration

Leucine
110 to 160
μmole/l

Isoleucine
54 to 75
μmole/l

Valine
210 to 290
μmole/l,

or the precursor composition is characterized in that the amino acid component consists of Valine, Leucine and Isoleucine and is present in an amount to yield upon mixing with a diluent in a dialysis fluid the respective amino acid concentration ranges of

Amio Acid
Concentration

Leucine
120 to 140
μmole/l

Isoleucine
65 to 75
μmole/l

Valine
260 to 280
μmole/l,

or the precursor composition is characterized in that the amino acid component consists of Valine, Leucine and Isoleucine and is present in an amount to yield upon mixing with a diluent in a dialysis fluid the respective amino acid concentration ranges of

Amio Acid
Concentration

Leucine
300 to 370
μmole/l

Isoleucine
180 to 240
μmole/l

Valine
580 to 680
μmole/l.

7. The precursor composition according to claim 1 , characterized in that the precursor composition is present in packaged form, and after being exposed to a temperature of 40° C. and a relative air humidity of 25% for 9 months, yields a 5-Hydroxymethylfurfural concentration of below 18 mg/l when prepared to yield a dialysis fluid.

8. The precursor composition according to claim 1 , characterized in that the respective components of the precursor composition are present in an amount to yield a dialysis fluid exhibiting the following concentration ranges

Component
Concentration

Citric Acid
1 to 20
mmole/l

Glucose
0.8 to 2.2
g/l

Sodium
110 to 170
mmole/l

Potassium
0.7 to 4.3
mmole/l

Magnesium
0.3 to 1.2
mmole/l

Calcium
0.1 to 2.2
mmole/l

Valine
110 to 160
μmole/l

Leucine
54 to 80
μmole/l

Isoleucine
210 to 290
μmole/l.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Luaire Benoit
• Laffay Philippe
• Chazot Charles
• Deleaval Patrik

Classifications

• A61K31/405

  Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title

• A61K31/198 Primary

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title

• A61K33/14

  Alkali metal chlorides; Alkaline earth metal chlorides · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title