Flowable composition

Patent metadata

Field	Value
Publication number	US-11141353-B2
Application number	US-201815996671-A
Country	US
Kind code	B2
Filing date	Jun 4, 2018
Priority date	Jun 6, 2017
Publication date	Oct 12, 2021
Grant date	Oct 12, 2021

Abstract

A dental composition comprising a pre-reacted particulate mineral trioxide aggregate (MTA) dispersed in a polymer matrix wherein the content of MTA in the composition is in the range of 20 to 50 percent by weight based on the total weight of the composition.

First claim

The invention claimed is:

1. A dental composition comprising a pre-reacted particulate of cured mineral trioxide aggregate (MTA) dispersed in a non-aqueous polymer matrix, wherein the content of cured particulate MTA is in the range of 20 to 50 by weight based on the total weight of the composition and wherein the pre-reacted particulate of cured MTA has an average particle size of from 0.1 to 100 microns; wherein the non-aqueous polymer matrix includes a silicone polymer or a polymerizable material selected from methacrylated polyisoprene, epoxy modified liquid polyisoprene or amine modified liquid polyisoprene.

2. The dental composition according to claim 1 , wherein the polymer matrix is present in an amount of 10 to 90 percent by weight based on the total weight of the composition.

3. The dental composition according to claim 1 , for use in endodontic treatment of a tooth.

4. The dental composition for use in the according to claim 3 , wherein the endodontic treatment is selected from the group consisting of root-end filling, apical plug for apexification, repair of root perforations, internal resorption, indirect pulp capping, direct pulp capping, obturation, and sealing the root canal.

5. The dental composition according to claim 1 , wherein the dental composition:
(i) is bio inductive for cementum;
(ii) stimulates a hard tissue covering where a blood supply exists thereby regenerating cementum creates a biological seal;
(iii) does not stimulate an inflammatory process,
(iv) supports tissue regeneration;
(v) is biocompatible with pulp and periradicular tissues; and/or
(vi) is not cytotoxic in the set or unset state.

6. The dental composition according to claim 1 , wherein the dental composition is antibacterial and/or antimicrobial due to a pH increase.

7. The dental composition according, to claim 1 , wherein the dental composition produces hydroxyapatite when exposed to either blood or simulated body fluid.

8. A process for the preparation of a dental composition comprising the steps of:
(i) providing a cured mineral trioxide aggregate MTA;
(ii) milling the cured MTA to an average particle size of from 0.1 to 100 microns to form a pre-reacted particulate of cured MTA;
(iii) dispersing the pre-reacted particulate of cured MTA in a non-aqueous polymer matrix for forming a composite composition; wherein the non-aqueous polymer matrix includes a silicone polymer or a polymerizable material selected from methacrylated polyisoprene, epoxy modified liquid polyisoprene or amine modified liquid polyisoprene.

9. The process according to claim 8 , wherein the dental composition:
(i) is bio inductive for cementum;
(ii) stimulates a hard tissue covering where a blood supply exists thereby regenerating cementum creates a biological seal;
(iii) does not stimulate an inflammatory process;
(iv) supports tissue regeneration;
(v) is biocompatible with pulp and periradicular tissues; and/or
(vi) is not cytotoxic in the set or unset state.

10. The process according to claim 8 , wherein the dental composition is antibacterial and/or antimicrobial due to a pH increase.

11. The process according to claim 8 , wherein the dental composition produces hydroxyapatite when exposed to either blood or simulated body fluid.

Assignees

• Dentsply Sirona Inc

Inventors

• Berger Todd Patrick
• Baratz Adam Zachary
• Rose Sheridan Lynn

Classifications

• A61K6/896

  Polyorganosilicon compounds · CPC title

• A61K6/17

  Particle size · CPC title

• A61K6/54 Primary

  Filling; Sealing · CPC title

• A61K6/56 Primary

  Apical treatment · CPC title

• A61K6/851

  Portland cements · CPC title