Method of sampling and/or depositing a sample of biological matter and device implementing such method
US-10144948-B2 · Dec 4, 2018 · US
US11136544B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11136544-B2 |
| Application number | US-201916699884-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 2, 2019 |
| Priority date | Mar 30, 2015 |
| Publication date | Oct 5, 2021 |
| Grant date | Oct 5, 2021 |
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Official abstract text for this publication.
A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
Opening claim text (preview).
The invention claimed is: 1. A method for collecting a specimen from a culture medium comprising: providing a device for collecting a specimen from a culture medium, wherein the device has a body comprising a cavity structure for receiving a replaceable picktool, the body and the picktool being in approximately axial alignment; and a detector configured to generate a signal in response to a force applied to the picktool when the picktool is brought into contact with the specimen disposed on the culture medium, wherein the device is configured to operate in at least first and second modes, wherein in the first mode the device does not apply resistance to movement of the body and the picktool in an axial direction, which is proximately perpendicular to a surface of the culture medium, and the second mode applies more resistance to axial movement of the body and the picktool than when the device is in the first mode; initiating the first mode of the device, wherein the device does not apply resistance to movement of the body in the axial direction relative to a support structure of the device; moving the device in the axial direction to receive and retain the picktool configured to collect the specimen; moving the picktool, by the device, into contact with the specimen disposed on the culture medium; initiating the second mode of the device and applying resistance to movement of the device in the axial direction, thereby precluding such movement; manipulating the picktool while the picktool is attached to the device to collect the specimen; and depositing the collected specimen at a collection location, wherein wherein the device further comprises a device structure coupled to the body, wherein the device does not lock the body from axial movement in the direction relative to the device structure in the first mode, and the body is locked from such axial movement in the axial direction in the second mode and a key coupled to the body, wherein the key cooperates with an opening in the device structure above the key so that the key does not engage and may advance into and through the device structure in the first mode and in which the key cannot advance into and through the device structure in the second mode. 2. The method of claim 1 , further comprising after depositing the collected specimen, processing the collected specimen, the step of processing the collected specimen including at least one of the processes selected from the group consisting of processing testing, culturing, or preserving. 3. The method of claim 1 , wherein the step of manipulating includes the device rotating the picktool. 4. The method of claim 1 , further comprising releasing the picktool from the device so as to discard the picktool. 5. The method of claim 1 , further comprising detecting the contact between the picktool and the culture medium. 6. The method of claim 5 , further comprising detecting a height at which the picktool contacts the culture medium. 7. The method of claim 1 , further comprising determining a height at which the picktool contacts the specimen. 8. The method of claim 1 , wherein in the second mode, increasing an amount of the resistance progressively with displacement of the body beyond a first predetermined range of motion. 9. The method of claim 8 , wherein, in the second mode, increasing an amount of the resistance as a step function upon a displacement of the body beyond the first predetermined range of motion. 10. The method of claim 8 , further comprising a spring, wherein the spring, in the second mode, resists axial movement of the body as a response to movement of the body at or following the contact between the picktool and the specimen disposed on the culture medium. 11. The method of claim 1 , further comprising the detector generating the signal as a response to detecting a relative position between the device and the specimen. 12. The method of claim 1 , further comprising switching from the first mode to the second mode when the picktool contacts or comes into contact with the specimen disposed on the culture medium. 13. The method of claim 1 , wherein the device further comprises a motor coupled to the body for rotating the body in a direction about an axis of the body, the motor being configured to rotate the body relative to the device structure between a first position corresponding to the first mode in which the key is advanced into and through the device structure and a second position corresponding to the second mode in which the key cannot advance into and through the device structure. 14. The method of claim 1 wherein the key comprises at least one lateral extension away from an axis common to the key and the body, and the opening is sized to permit the at least one lateral extension to pass therethrough. 15. The method of claim 1 , wherein the device further comprises a sleeve through which the body extends, wherein in the first mode the device does not apply the resistance to the movement of the body in the axial direction within the sleeve and the sleeve restrains the body in coaxial arrangement therewith, and in the second mode the sleeve and the device structure apply the resistance to movement of the body relative to the device structure.
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