Water-soluble acetaminophen analogs
US-2020002364-A1 · Jan 2, 2020 · US
US11136342B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11136342-B2 |
| Application number | US-201916459430-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 1, 2019 |
| Priority date | May 20, 2008 |
| Publication date | Oct 5, 2021 |
| Grant date | Oct 5, 2021 |
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The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.
Opening claim text (preview).
What is claimed is: 1. A formulation comprising: (i) a prodrug comprising: (a) a moiety of parent drug, wherein the parent drug comprises a hydroxyl group or a carboxyl group; and (b) a prodrug moiety of the formula: wherein the prodrug moiety is bound to the moiety of the parent drug at the hydroxyl or carboxyl group providing a carbonate moiety; or a pharm…
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