Ophthalmic compositions

Patent metadata

Field	Value
Publication number	US-11129862-B2
Application number	US-201816113073-A
Country	US
Kind code	B2
Filing date	Aug 27, 2018
Priority date	Aug 30, 2017
Publication date	Sep 28, 2021
Grant date	Sep 28, 2021

Abstract

The present invention relates to compositions providing improved substantivity, comfort and/or feel to the eye upon application. The present invention further relates to compositions comprising a cellulose derivative in combination with tamarind seed extract and hyaluronic acid in ratios that mimic the physical properties of human tears on the eye.

First claim

What is claimed is:

1. An ophthalmic composition, comprising:
a.) a polymer mixture comprising
i. a cellulose derivative;
ii a tamarind seed extract; and
iii hyaluronic acid;

b.) a polyquaternium compound selected from polyquaternium-1, polyquaternium-10, polyquaternium-42 or mixtures;
c.) from 0.4% w/v to about 1.5% w/v of the total composition of a polyol and
d.) an aqueous component comprising greater than about 50% by weight, of the total composition, of water
wherein the total concentration of the polymer mixture of cellulose derivative, tamarind seed extract and hyaluronic acid is between greater than about 0.4% to about 0.9%, by weight, of the total composition and further wherein the cellulose derivative, tamarind seed extract and hyaluronic acid are combined at a ratio of: 1 to 10 parts cellulose derivative: 1 to 4 parts tamarind seed extract: 1 to 2 parts hyaluronic acid, to form the polymer mixture such that the composition has:
i. a viscosity of from about 30 to 100 cps at zero shear as measured by the AR2000 Flow Test Method; and
ii. a viscosity of less than 30 cps at a shear rate of blinking of 1/100 sec. as measured by the AR2000 Flow Test Method

and wherein the composition is formulated as a sterile aqueous solution.

2. The composition of claim 1 wherein the cellulose derivative is selected from (hydroxyalkyl cellulose polymers, alkyl hydroxyalkyl cellulose polymers; methyl cellulose; methyl cellulose derivatives; hydroxymethycellulose derivatives; and mixtures thereof.

3. The composition of claim 2 , wherein the hydroxyalkyl cellulose polymers are selected from hydroxyethyl cellulose, hydroxypropyl cellulose and mixtures thereof.

4. The composition of claim 2 , wherein the alkyl hydroxyalkyl cellulose polymers is cetyl hydroxyethyl cellulose.

5. The composition of claim 2 , wherein the methyl cellulose derivative is selected from carboxymethyl cellulose, hydroxymethyl cellulose, a hydroxymethyl cellulose derivative or mixtures thereof.

6. The composition of claim 5 , wherein the hydroxymethyl cellulose derivative is selected from hydroxypropyl methylcellulose, hydroxybutyl methyl cellulose or mixtures thereof.

7. The composition of claim 1 , wherein any non-ionic and anionic polymers in the composition are present at a the total concentration from about 0.4% to about 1.0%, by weight, of the total composition.

8. The composition of claim 1 , wherein the surface tension of the composition ranges from about 40.8 dynes/cm to 51.9 dynes/cm as measured by the Rame-Hart—DROPimage Advanced Software Pendant Drop Method.

9. The composition of claim 1 , wherein the rate of moisture loss for the composition is less than 1 mg/3 minutes at 37° C. and 70% relative humidity as measured by the DVS Intrinsic Measurement System and DVS-Intrinsic Control Software Method.

10. The composition of claim 1 , wherein the composition has an elastic modulus G′ greater than 0.70 (or about 0.70) Pascals and a phase angle δ of from about 40° to about 65° as measured by the Bohlin CVOR Rheometer Visco-Elastic Property Test Method.

11. The composition of claim 1 , wherein the composition has:
i. a surface tension ranging from about 40.8 dynes/cm to 51.9 dynes/cm as measured by the Rame-Hart—DROPimage Advanced Software Pendant Drop Method;
ii. a rate of moisture loss of less than 1 mg/3 minutes at 37° C. and 70% relative humidity as measured by the DVS Intrinsic Measurement System and DVS-Intrinsic Control Software Method;
iii. an elastic modulus G′ greater than 0.70 (or about 0.70) Pascals and a phase angle δ of from about 40° to about 65° as measured by the Bohlin CVOR Rheometer Visco-Elastic Property Test Method.

Assignees

• Johnson & Johnson Consumer Inc

Inventors

• Bai Mingqi
• Holeva Kenneth T

Classifications

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title

• A61K9/0048

  Eye, e.g. artificial tears · CPC title

• A61K31/717 Primary

  Celluloses · CPC title

• A61K31/715

  Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters · CPC title