Uses of soluble corn fiber for increasing colonic bacteria populations and increasing mineral absorption

Patent metadata

Field	Value
Publication number	US-11129403-B2
Application number	US-201414778883-A
Country	US
Kind code	B2
Filing date	Mar 22, 2014
Priority date	Mar 22, 2013
Publication date	Sep 28, 2021
Grant date	Sep 28, 2021

Abstract

The present invention relates to fermentable soluble fibers, such as soluble corn fiber (SCF), and its uses in increasing colonic bacteria populations, and edible compositions useful in increasing colonic bacteria populations.

First claim

We claim:

1. An edible composition for increasing one or more colonic bacteria populations in a subject, the edible composition comprising soluble corn fiber and one or more bacterial populations, wherein at least one of the one or more bacteria populations is of a genus selected from the group consisting of Parabacteroides, Oscillibacter, Alisupes , and Anaerococcus , wherein the soluble corn fiber is made by a process comprising:
providing an aqueous feed composition that comprises a syrup made by hydrolysis of corn starch, the aqueous feed composition comprising linear dextrose oligomers, and that has a solids concentration of at least 90% by weight; and
contacting the feed composition for a time in the range of 0.1-15 minutes at a temperature of at least 149° C. with at least one catalyst that accelerates the rate of cleavage or formation of glucosyl bonds for a time sufficient to cause formation of non-linear dextrose oligomers, wherein the at least one catalyst is an acid added to the feed composition in an amount sufficient to make the pH of the feed composition 1.0-2.5, wherein a product composition is formed in which the concentration of non-linear dextrose oligomers is at least twice as high as the concentration of linear dextrose oligomers, and in which the concentration of non-linear dextrose oligomers having a degree of polymerization of at least three is at least 50% by weight on a dry solids basis, the product composition being primarily digestion resistant, the product composition including less than 50% on a dry solids basis of residual monosaccharides,
wherein the dextrose oligomers have a degree of polymerization of 2 to 30.

2. The edible composition of claim 1 , further comprising one or more bacteria populations, each of a different genus selected from the group consisting of Bacteroides and Dialister.

3. The edible composition of claim 1 , comprising one or more bacteria populations, each of a genus selected from the group consisting of Parabacteroides , and Oscillibacter.

4. The edible composition of claim 1 , wherein at least one of the one or more bacteria populations is of a genus selected from the group consisting of Parabacteroides, Alistipes , and Anaerococcus.

5. The edible composition of claim 1 , wherein at least one of the one or more bacterial populations is of the genus Oscillibacter.

6. The edible composition of claim 1 , further comprising a bacterial population of the genus Dialister.

7. The edible composition of claim 1 , wherein the composition comprises at least 2.5 g of soluble corn fiber per serving.

8. The edible composition of claim 1 , wherein the composition further comprises calcium.

9. The edible composition according to claim 8 , wherein the calcium is provided at an amount of at least about 50 mg mineral per dose or serving.

10. The edible composition of claim 1 , wherein the composition is provided in a form selected from baked foods, breakfast cereal, dairy products, soy products, confections, jams and jellies, beverages (powdered and/or liquid), shakes, fillings, yogurts (dairy and non-dairy yogurts), kefirs, extruded and sheeted snacks, gelatin desserts, snack bars, meal replacement and energy bars, cheese and cheese sauces (dairy and non-dairy cheeses), edible and water-soluble films, soups, syrups, table top sweeteners, nutritional supplements, sauces, dressings, creamers, icings, ice cream, frostings, glazes, pet food, tortillas, meat and fish, dried fruit, infant and toddler food, and batters and breadings.

11. The edible composition of claim 1 , wherein the food composition is in the form of an agglomerated powder, a nutritional supplement or a medicinal dosage form.

12. The edible composition of claim 1 , further comprising a bacterial population of the genus Bifidobacterium.

13. The edible composition of claim 1 , further comprising a bacterial population of the genus Bacteroides or the genus Dialister.

14. The method of claim 1 , wherein at least one of the one or more bacterial populations is of the genus Alistipes , or Anaerococcus.

15. A method of increasing one or more colonic bacteria populations in a mammalian subject, each of a genus selected from the group consisting of Parabacteroides, Oscillibacter, Alistipes , and Anaerococcus , the method comprising administering to the subject an edible composition comprising soluble corn fiber and one or more bacterial populations, wherein at least one of the one or more bacteria populations is of a genus selected from the group consisting of Parabacteroides, Oscillibacter, Alistipes , and Anaerococcus , wherein the soluble corn fiber is made by a process comprising:
providing an aqueous feed composition that comprises a syrup made by hydrolysis of corn starch, the aqueous feed composition comprising linear dextrose oligomers, and that has a solids concentration of at least 90% by weight; and
contacting the feed composition for a time in the range of 0.1-15 minutes at a temperature of at least 149° C. with at least one catalyst that accelerates the rate of cleavage or formation of glucosyl bonds for a time sufficient to cause formation of non-linear dextrose oligomers, wherein the at least one catalyst is an acid added to the feed composition in an amount sufficient to make the pH of the feed composition 1.0-2.5, wherein a product composition is formed in which the concentration of non-linear dextrose oligomers is at least twice as high as the concentration of linear dextrose oligomers, and in which the concentration of non-linear dextrose oligomers having a degree of polymerization of at least three is at least 50% by weight on a dry solids basis, the product composition being primarily digestion resistant or primarily slowly digestible, the product composition including less than 50% on a dry solids basis of residual monosaccharides,

wherein the dextrose oligomers have a degree of polymerization of 2 to 30.

16. The method according to claim 15 , wherein one or more of the colonic bacteria populations is increased by at least about 10% as compared to a non-treated subject.

17. The method according to claim 15 , wherein the administration is performed such that fecal pH is reduced by at least about 1.5 pH units.

18. The method according to claim 15 , wherein the increase in colonic bacteria population and/or the decrease in pH results in an increase in the bioavailability of calcium.

19. The method according to claim 15 , wherein the method further increases calcium absorption by at least about 35% in the subject.

20. The method according to claim 15 , wherein the soluble corn fiber is administered at a rate of at least about 2.5 g/day.

21. The method according to claim 15 , wherein at least one of the one or more bacterial populations is of the genus Oscillibacter.

22. The method according to claim 15 , wherein the administration is performed over the course of at least two weeks.

23. The method of claim 15 , wherein at least one of the one or more bacterial populations is of the genus Parabacteroides, Alistipes , or Anaerococcus.

24. A method of increasing one or more colonic bacteria populations in a mammalian subject, each of a genus selected from the group consisting of Parabacteroides, Oscillibacter, Alistipes , and Anaerococcus , the method comprising administering to the subject an edible composition comprising soluble corn fiber and one or more bacterial populations, whe

Assignees

• Tate & Lyle Ingredients Americas Llc
• Purdue Research Foundation

Inventors

• Weaver Connie Marie
• Nakatsu Cindy H
• Williamson Patricia
• Hoffman Andrew Joseph
• Sanders Lisa Marie

Classifications

• A23L33/21 Primary

  Addition of substantially indigestible substances, e.g. dietary fibres · CPC title

• A23L33/22

  Comminuted fibrous parts of plants, e.g. bagasse or pulp · CPC title

• A23L33/30 Primary

  Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence) · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title