Process for the preparation of powder compositions

Patent metadata

Field	Value
Publication number	US-11123394-B2
Application number	US-201716469826-A
Country	US
Kind code	B2
Filing date	Nov 30, 2017
Priority date	Dec 15, 2016
Publication date	Sep 21, 2021
Grant date	Sep 21, 2021

Abstract

Disclosed is a process for the preparation of powder compositions including a lipophilic extract of Echinacea spp., a lipophilic extract of Zingiber officinale and phospholipids. Also disclosed are powder compositions obtainable by the process and pharmaceutical, nutraceutical and cosmetic formulations including the compositions. Also described is a use of the powder compositions and formulations thereof in the prevention and/or treatment of inflammatory and painful states.

First claim

The invention claimed is:

1. A powder composition obtainable by a manufacturing process comprising the following steps:
a) dispersing a lipophilic extract of Echinacea spp., or a botanical lipophilic extract containing alkylamides selected from a lipophilic extract of Zanthoxylum spp. or Acmella spp., and a lipophilic extract of Zingiber officinale in at least one polar organic solvent and mixing until a solution or a suspension is obtained;
b) adding at least one phospholipid to the solution, or suspension, of the lipophilic extracts and mixing the mixture;
c) removing the organic solvent to obtain the powder composition;
wherein a weight ratio of the lipophilic extracts to the at least one phospholipid is from 0.2 to 2.

2. The powder composition of claim 1 , wherein the weight ratio of the lipophilic extracts to the at least one phospholipid is from 0.5 to 1.

3. The powder composition of claim 2 , wherein the weight ratio of the lipophilic extracts to the at least one phospholipid is 1.

4. The powder composition of claim 1 , wherein the lipophilic extract is obtained from Acmella oleracea.

5. The powder composition of claim 1 , wherein the phospholipid is selected from lecithins derived from soy, sunflower or egg, phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine, wherein acyl groups are the same or different and are mostly derived from palmitic, stearic, oleic, linoleic, linolenic acids; and combinations thereof.

6. The powder composition of claim 4 , wherein the phospholipid is lecithin.

7. The powder composition of claim 6 , wherein the lecithin is sunflower lecithin.

8. The powder composition of claim 1 , wherein after step b) an additional ingredient is added to the solution or suspension obtained in step a).

9. The powder composition of claim 8 , wherein the additional ingredient is a second surfactant, other than lecithin.

10. The powder composition of claim 9 , wherein the second surfactant is selected from the group consisting of polyoxyethylene castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, polyglycerides, sorbitan fatty acid esters, sucrose palmitate, sucrose stearate, D-α-tocopheryl polyethylene glycol succinate, and combinations thereof.

11. The powder composition of claim 9 , wherein a weight ratio of the phospholipid to second surfactant is from 0.25 to 10.

12. The powder composition of claim 11 , wherein the weight ratio of the phospholipid to second surfactant is from 0.5 to 1.

13. The powder composition of claim 11 , wherein the weight ratio of the phospholipid to second surfactant is from 1.2 to 10.

14. The powder composition of claim 1 , wherein a weight ratio of the lipophilic extract of Echinacea spp., or a botanical lipophilic extract containing alkylamides selected from a lipophilic extract of Zanthoxylum spp. or Acmella spp. to the lipophilic extract of Zingiber officinale is 0.2.

15. Pharmaceutical, nutraceutical and cosmetic formulations comprising a powder composition according to claim 1 and at least one physiologically acceptable excipient and/or carrier.

16. A powder composition obtainable by a manufacturing process comprising the following steps:
a) dispersing a lipophilic extract of Echinacea spp. from 10 g to 25 g, or a botanical lipophilic extract containing alkylamides selected from a lipophilic extract of Zanthoxylum spp. or Acmella spp. equal to 7.5 g, and a lipophilic extract of Zingiber officinale from 37.5 g to 125 g in at least one polar organic solvent and mixing until a solution or a suspension is obtained;
b) adding at least one phospholipid from 45 to 150 g to the solution, or suspension, of the lipophilic extracts and mixing the mixture;
c) removing the organic solvent to obtain the powder composition;
wherein a weight ratio of the lipophilic extracts to the at least one phospholipid is from 0.2 to 2.

17. The powder composition of claim 1 , wherein after step b) additional ingredients are added to the obtained solution, or suspension, of lipophilic extracts and phospholipid, which is kept under mixing.

18. The powder composition of claim 17 , wherein the additional ingredients are selected from microcrystalline cellulose, powdered cellulose, methylcellulose, hydroxypropyl cellulose, carboxymethyl cellulose, hydroxypropylmethyl cellulose.

19. The powder composition of claim 17 , wherein the additional ingredients are selected from microcrystalline cellulose, hydroxypropyl cellulose.

Assignees

• Indena Spa

Inventors

• Ronchi Massimo
• Frattini Elisabetta

Classifications

• A61K36/9068

  Zingiber, e.g. garden ginger · CPC title

• A61K36/758 Primary

  Zanthoxylum, e.g. pricklyash · CPC title

• A61K36/28 Primary

  Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea · CPC title

• A61K31/685

  one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin · CPC title

• A61K9/14

  Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)} · CPC title