Ion generation using modified wetted porous materials

Patent metadata

Field	Value
Publication number	US-11119081-B2
Application number	US-202016905193-A
Country	US
Kind code	B2
Filing date	Jun 18, 2020
Priority date	Jun 3, 2011
Publication date	Sep 14, 2021
Grant date	Sep 14, 2021

Abstract

The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

First claim

What is claimed is:

1. A sample analysis system comprising:
a cartridge configured to hold at least a portion of a porous substrate within a body of the cartridge, and an electrode incorporated into the body of the cartridge such that when the porous substrate is disposed within the cartridge, the electrode connects to the the porous substrate.

2. The system according to claim 1 , wherein the system further comprises a mass spectrometer and the system is configured such that the cartridge is positioned with respect to an inlet of the mass spectrometer so that a tip of the porous substrate is aligned with the inlet of the mass spectrometer.

3. The system according to claim 1 , wherein the cartridge further comprises the porous substrate.

4. The system according to claim 3 , wherein the porous substrate is paper.

5. The system according to claim 4 , wherein the paper is filter paper.

6. The system according to claim 3 , wherein the porous substrate is wetted.

7. The system according to claim 3 , wherein the porous substrate comprises a sample.

8. The system according to claim 3 , wherein a surface of the porous substrate comprises a material that modifies an interaction between a sample and the porous substrate.

9. The system according to claim 3 , wherein the porous substrate comprises an internal standard.

10. The system according to claim 1 , wherein a distal end of the cartridge forms an open cylinder that protects a tip of the porous substrate that protrudes from the cartridge.

11. A sample analysis system comprising:
a cartridge configured to hold a porous substrate and an electrode that operably connects with the porous substrate when the porous substrate is at least partially disposed within the cartridge, wherein the cartridge further comprises a bottom portion and a detachable cover, and the cartridge is configured such that the bottom portion is configured to hold the porous substrate and the cartridge is configured such that voltage is not supplied to the porous substrate in the cartridge until the detachable cover is connected to the bottom portion.

12. The system according to claim 11 , wherein the system further comprises a mass spectrometer and the system is configured such that the cartridge is positioned with respect to an inlet of the mass spectrometer so that a tip of the porous substrate is aligned with the inlet of the mass spectrometer.

13. The system according to claim 11 , wherein the cartridge further comprises the porous substrate.

14. The system according to claim 13 , wherein the porous substrate is paper.

15. The system according to claim 14 , wherein the paper is filter paper.

16. The system according to claim 13 , wherein the porous substrate is wetted.

17. The system according to claim 13 , wherein the porous substrate comprises a sample.

18. The system according to claim 13 , wherein a surface of the porous substrate comprises a material that modifies an interaction between a sample and the porous substrate.

19. The system according to claim 13 , wherein the porous substrate comprises an internal standard.

20. The system according to claim 11 , wherein a distal end of the cartridge forms an open cylinder that protects a tip of the porous substrate that protrudes from the cartridge.

Assignees

• Purdue Research Foundation

Inventors

• Cooks Robert Graham
• Ouyang Zheng

Classifications

• H01J49/168 Primary

  field ionisation, e.g. corona discharge (atmospheric pressure corona discharge per se H01T19/00) · CPC title

• H01J49/0409

  Sample holders or containers (containers for retaining a material to be analyzed, B01L3/50, for DNA, C12Q1/6834, for biological materials, G01N33/543) · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01J49/167

  Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00) · CPC title

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title