Use of an rxr agonist in treating her2+ cancers
US-2021137871-A1 · May 13, 2021 · US
US11118852B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11118852-B2 |
| Application number | US-202017038437-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 30, 2020 |
| Priority date | Oct 4, 2019 |
| Publication date | Sep 14, 2021 |
| Grant date | Sep 14, 2021 |
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A rifle with a barrel firmly mounted in a framework, the barrel including a locking sleeve, a lock, a sliding block, and a gas-powered actuator. Advantageously quiet operation of the gas-powered actuator is accomplished when the actuator has an annular piston, which is movable on a plunger support, forming an expansion chamber, where the actuator acts on the sliding block via push rods and is pushed forward by reset springs, and the rifle further includes a gas borehole penetrating the walls of the barrel and the plunger support, and further where the plunger support includes an outlet channel in its front, upper range, which is fluidly separate from the expansion chamber when the annular piston is at rest, and is fluidly connected with the expansion chamber after a backward displacement of the annular piston.
Opening claim text (preview).
What is claimed is: 1. A firearm, comprising: a framework; a barrel that is firmly mounted within the framework, the barrel defining an operating axis; a locking sleeve that is connected to the barrel, the locking sleeve including a lock, a sliding block, and a gas-powered actuator; wherein the gas-powered actuator includes: a plunger support having an annular piston that is located in a displaceable manner on the plunger support; an annular expansion chamber in a region behind a front surface of the annular piston, the annular expansion chamber being defined by an axial section of the annular piston having a reduced internal radius in combination with the plunger support; wherein the expansion chamber: is fluidly connected with a gas borehole penetrating a wall of the barrel and the plunger support; is urged in a forward direction by one or more reset springs; and is configured to act upon the sliding block by way of one or more push rods; the gas-powered actuator further comprising an outlet channel defined by a foremost protruding portion of the annular piston in combination with an overflow limit of the plunger support and a region forward of the overflow limit; and wherein the outlet channel is fluidly separated from the expansion chamber when the annular piston is at rest, and is fluidly connected with the expansion chamber after a backward displacement of the annular piston. 2. The firearm according to claim 1 , wherein when the annular piston is at rest the front surface of the annular piston contacts the overflow limit on the plunger support, thereby fluidly separating the outlet channel and the expansion chamber. 3. The firearm of claim 1 , wherein the firearm is a rifle. 4. The firearm of claim 1 , wherein the annular piston includes a plurality of outlet channels, each having a different geometrical design than the other outlet channels. 5. The firearm of claim 4 , wherein each of the plurality of outlet channels corresponds to a distinct energy selector length. 6. The firearm of claim 4 , further comprising an adapter that is axially disposed between the annular piston and the locking sleeve; wherein a forward front face of the adapter extends in a corrugated manner with respect to an axis normal to the operating axis; and a rear-facing surface of the annular piston is corrugated in a complementary manner to the forward front face of the adapter. 7. The firearm of claim 1 , further comprising a labyrinth seal disposed between the plunger support and the annular piston. 8. The firearm of claim 1 , wherein the plunger support defines an internal contour incorporating a plurality of recesses. 9. The firearm of claim 6 , further comprising a positional fixation about the operating axis that is configurable by way of at least one gradation that is complementary in shape to the adapter. 10. The firearm of claim 1 , wherein the locking sleeve includes a plurality of lateral guide extensions. 11. The firearm of claim 1 , wherein each of the one or more push rods has a one-piece design. 12. The firearm of claim 1 , wherein the annular piston includes a plurality of blind holes in the circumferential direction. 13. A rifle, comprising: a framework; a barrel that is firmly mounted within the framework, the barrel defining an operating axis; a locking sleeve that is connected to the barrel, the locking sleeve including a lock, a sliding block, and a gas-powered actuator; wherein the gas-powered actuator includes: a plunger support having an annular piston that is located in a displaceable manner on the plunger support, the annular piston including a plurality of outlet channels, each outlet channel having a different geometrical design than the other outlet channels, and each outlet channel corresponding to a distinct energy selector length; an annular expansion chamber in a region behind a front surface of the annular piston, the annular expansion chamber being defined by an axial section of the annular piston having a reduced internal radius in combination with the plunger support; wherein the expansion chamber: is fluidly connected with a gas borehole penetrating a wall of the barrel and the plunger support; is urged in a forward direction by one or more reset springs; and is configured to act upon the sliding block by way of one or more unitary push rods; the gas-powered actuator further comprising an outlet channel defined by a foremost protruding portion of the annular piston in combination with an overflow limit of the plunger support and a region forward of the overflow limit; and wherein the outlet channel is fluidly separated from the expansion chamber when the annular piston is at rest, and is fluidly connected with the expansion chamber after a backward displacement of the annular piston. 14. The rifle of claim 13 , further comprising an adapter that is axially disposed between the annular piston and the locking sleeve; wherein a forward front face of the adapter extends in a corrugated manner with respect to an axis normal to the operating axis; and a rear-facing surface of the annular piston is corrugated in a complementary manner to the forward front face of the adapter. 15. The rifle of claim 13 , further comprising a labyrinth seal disposed between the plunger support and the annular piston. 16. The rifle of claim 13 , wherein the plunger support defines an internal contour incorporating a plurality of recesses. 17. The rifle of claim 14 , further comprising a positional fixation about the operating axis that is configurable by way of at least one gradation that is complementary in shape to the adapter. 18. The rifle of claim 13 , wherein the locking sleeve includes a plurality of lateral guide extensions. 19. The rifle of claim 13 , wherein the annular piston includes a plurality of blind holes in a circumferential direction.
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