High gas flow rate bio-reactive container filter apparatus

Patent metadata

Field	Value
Publication number	US-11118152-B2
Application number	US-201916577746-A
Country	US
Kind code	B2
Filing date	Sep 20, 2019
Priority date	Mar 5, 2015
Publication date	Sep 14, 2021
Grant date	Sep 14, 2021

Abstract

A bio-reactive container and filter assembly to improve flow rates and mass transfer without increased pressure. An inlet filter membrane secured to the container defines a container chamber in combination with the container. An inlet filter membrane element may also be secured to the container to provide structural support to the membrane. An outlet membrane secured to the container defines a container chamber in combination with the container. An outlet filter membrane element may also be secured to the container to provide structural support to the outlet membrane. Inlet and/or outlet filters and/or filter elements are constructed to significantly increase surface area available for fluid and/or gas ingress and/or egress. Single and double layer membranes with mixtures of hydrophobic and hydrophilic characteristics are used to maximize perfusion and gasification/degasification of bio-reactive containers.

First claim

What we claim as new and desire to secure by United States Letters Patent is:

1. A container assembly for performing biological and pharmaceutical processes and reactions comprising:
an enclosed container having a pliable impermeable container sidewall defining a sidewall bottom end and a sidewall top end;
a selectively-permeable container bottom wall consisting of a bottom filter membrane filtration barrier secured to the container sidewall bottom end wherein the bottom filter membrane filtration barrier functions as a bottom end of the container, and wherein the bottom filter membrane filtration barrier functions as an inlet; and,
a selectively-permeable container top wall consisting of a top filter membrane filtration barrier secured to the container sidewall top end wherein the top filter membrane filtration barrier functions as a top end of the container, wherein the top filter membrane filtration barrier functions as an outlet, and wherein the combination of the impermeable container sidewall, the selectively-permeable container bottom wall and the selectively-permeable container top wall define an enclosed chamber.

2. The container assembly of claim 1 wherein the assembly further comprises a filter support secured to the assembly wherein the support provides structural reinforcement to the bottom filter membrane filtration barrier.

3. The container assembly of claim 2 wherein the filter support defines a perimeter shoulder, wherein the bottom filter membrane filtration barrier is dimensioned and structured to fit within the perimeter shoulder.

4. The container assembly of claim 3 further comprising a lower support membrane positioned adjacent a lower side of the bottom filter membrane filtration barrier.

5. The container assembly of claim 4 further comprising an upper support membrane positioned adjacent to an upper side of the bottom filter membrane filtration barrier.

6. The container assembly of claim 5 further comprising a rigid support secured to the upper support membrane.

7. The container assembly of claim 6 further comprising a sealing band superposed about the bottom filter membrane filtration barrier, the lower support membrane, the upper support membrane and the rigid support.

8. The container assembly of claim 1 further comprising a rigid support secured to the bottom filter membrane filtration barrier.

9. The container assembly of claim 1 wherein the assembly further comprises a filter support secured to the assembly wherein the support provides structural reinforcement to the top filter membrane filtration barrier.

10. The container assembly of claim 9 wherein the assembly further comprises an outlet filter support secured to the assembly wherein the support provides structural reinforcement to the top filter membrane filtration barrier.

11. The container assembly of claim 10 wherein the filter support defines a perimeter shoulder, wherein the top filter membrane filtration barrier is dimensioned and structured to fit within the perimeter shoulder.

12. The container assembly of claim 11 further comprising a top filter membrane lower support membrane positioned adjacent a lower side of the top filter membrane filtration barrier.

13. The container assembly of claim 12 further comprising a top filter membrane upper support membrane positioned adjacent to an upper side of the top filter membrane filtration barrier.

14. The container assembly of claim 13 further comprising a rigid support secured to the top filter membrane upper support membrane.

15. The container assembly of claim 14 further comprising a sealing band superposed about the top filter membrane filtration barrier, the top filter membrane lower support membrane, the top filter membrane upper support membrane and the top filter membrane rigid support.

16. The container assembly of claim 1 further comprising a rigid support secured to the top filter membrane filtration barrier.

17. A container assembly for performing biological and pharmaceutical processes and reactions comprising:
an enclosed container having a pliable impermeable container sidewall defining a sidewall bottom end and a sidewall top end;
a selectively-permeable container top wall consisting of a top filter membrane filtration barrier secured to the container sidewall top end wherein the top filter membrane functions as a top end of the container, wherein the top filter membrane functions as an inlet; and,
a selectively-permeable container bottom wall consisting of a bottom filter membrane filtration barrier secured to the container sidewall bottom end wherein the membrane functions as a bottom end of the container, wherein the bottom filter membrane functions as an outlet, and wherein the combination of the impermeable container sidewall, the selectively-permeable container bottom wall and the selectively-permeable container top wall define an enclosed chamber.

18. The container assembly of claim 17 wherein the assembly further comprises a first filter support secured to the assembly adjacent the top filter membrane filtration barrier and a second filter support secured to the assembly adjacent the bottom filter membrane filtration barrier, wherein the first filter support provides structural reinforcement to the top filter membrane filtration barrier, and wherein the second filter support provides structural reinforcement to the bottom filter membrane filtration barrier.

19. The container assembly of claim 18 wherein the first filter support defines a first perimeter shoulder, wherein the top filter membrane filtration barrier is dimensioned to fit within the first perimeter shoulder, and wherein the second filter support defines a second perimeter shoulder, wherein the bottom filter membrane filtration barrier is dimensioned to fit within the second perimeter shoulder.

20. The container assembly of claim 19 further comprising a first lower support membrane positioned adjacent a lower side of the top filter membrane filtration barrier and a first sealing band superposed about the top filter membrane filtration barrier and the first lower support membrane, and a second lower support membrane positioned adjacent a lower side of the bottom filter membrane filtration barrier and a second sealing band superposed about the bottom filter membrane filtration barrier and the second lower support membrane.

Assignees

• Saint Gobain Performance Plastics Corp
• Saint_Gobain Performance Plastics Corp

Inventors

• Lin Zhenwu
• Renfrew Kenneth James
• Andrews Jacob

Classifications

• C12M33/14 Primary

  with filters, sieves or membranes · CPC title

• B01D63/00

  Apparatus in general for separation processes using semi-permeable membranes · CPC title

• C12M23/14

  Bags · CPC title