Compounds, compositions and methods for treatment of myopia

Patent metadata

Field	Value
Publication number	US-11117869-B2
Application number	US-202016779188-A
Country	US
Kind code	B2
Filing date	Jan 31, 2020
Priority date	Feb 1, 2019
Publication date	Sep 14, 2021
Grant date	Sep 14, 2021

Abstract

Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

First claim

What is claimed is:

1. A compound, wherein the compound is:

or a solvate, polymorph or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is:

or a solvate, polymorph thereof, or a pharmaceutically acceptable salt thereof.

Assignees

• Aerie Pharmaceuticals Inc

Inventors

• Carlson Eric
• Delong Mitchell A
• Gordhan Heeren
• Lichorowic Cynthia L
• Sturdivant Jill M

Classifications

• C07D451/06

  Oxygen atoms · CPC title

• C07D451/04

  with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system · CPC title

• C07D451/02 Primary

  containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof · CPC title

• C07D405/12

  linked by a chain containing hetero atoms as chain links · CPC title

• C07D239/26 Primary

  with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms · CPC title