Antibacterial medical implant surface

Patent metadata

Field	Value
Publication number	US-11116877-B2
Application number	US-201815927428-A
Country	US
Kind code	B2
Filing date	Mar 21, 2018
Priority date	Mar 21, 2017
Publication date	Sep 14, 2021
Grant date	Sep 14, 2021

Abstract

Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.

First claim

What is claimed is:

1. A system for preventing bacterial infection associated with medical implant procedures, comprising:
a silicon film comprising a controlled pattern of a plurality of nanopillars that have been etched into a silicon base, the plurality of nanopillars spaced apart at regular intervals comprising a pitch of 400 to 450 nm, the plurality of nanopillars formed by:
patterning a photoresist to expose a surface of the silicon base;
depositing a metal layer on a top surface of the photoresist and on the exposed surface of the silicon base;
removing the photoresist to lift off portions of the metal layer on the top surface of the photoresist; and
recessing portions of the silicon base under remaining portions of the metal layer using a metal-assisted chemical etch, wherein the metal-assisted chemical etch is locally restricted to an interface between the remaining portions of the metal layer and the exposed surface of the silicon base;

wherein each of the plurality of nanopillars has a top pillar diameter within a range from about 1 nanometer to about 200 nanometers; and
wherein each of the plurality of nanopillars has a same height.

2. The system according to claim 1 , further comprising a biocompatible film.

3. The system according to claim 2 , wherein the biocompatible film coats a surface of the plurality of nanopillars.

4. The system according to claim 2 , wherein the biocompatible film comprises titanium.

5. The system according to claim 2 , wherein the biocompatible film forms a conformal coating on the plurality of nanopillars.

6. The system according to claim 2 , wherein the biocompatible film comprises a conductive metal.

7. The system according to claim 6 , wherein the conductive metal film comprises platinum, silver, aluminum, nickel, titanium, or alloys thereof.

8. The system according to claim 2 , wherein the biocompatible film comprises aluminum oxide, hydroxyapatite, silicon dioxide, titanium carbide, titanium nitride, titanium dioxide, zirconium dioxide, calcium phosphate, chromium nitride, collagen, chitosan, cellulose or cellulose derivatives, poly-/-lactic acid (PLLA), poly(ε-caprolactone) (PCL), poly(lactide-co-glycolide) (PLGA), poly(ether imide) (PEI), poly(1,3-trimethylene carbonate) (PTMC), poly(styrene sulfonate) (PSS), or combinations thereof.

9. The system according to claim 2 , wherein the biocompatible film comprises nitrides, oxides, metallic oxides, metallic hydroxides, nanoporous inorganic coatings, natural polymers, synthetic polymers, or a combinations thereof.

10. The system according to claim 2 , wherein the biocompatible film comprises titanium nitride.

11. The system according to claim 1 , wherein the silicon base has a thickness of less than or equal to about 100 micrometers.

12. The system according to claim 1 , wherein the silicon film has a thickness of about 1 micron to about 100 microns.

13. The system according to claim 1 , wherein the silicon film is flexible.

14. The system according to claim 1 , wherein the silicon film is adhered to a surface of a medical implant device.

15. The system according to claim 14 , wherein the medical implant device allows human cell adherence or growth.

16. The system according to claim 1 , wherein the silicon film has a thickness of less than 50 micrometers.

Assignees

• IBM

Inventors

• Gifford Stacey M
• Hu Huan
• Kinser Emily R
• Yu Roy R
• Zafar Sufi

Classifications

• B81C1/00206 Primary

  Processes for functionalising a surface, e.g. provide the surface with specific mechanical, chemical or biological properties · CPC title

• B82B3/0033

  Manufacture or treatment of substrate-free structures, i.e. not connected to any support · CPC title

• B81B2207/056

  of static structures · CPC title

• A61L27/306

  Other specific inorganic materials not covered by A61L27/303 - A61L27/32 · CPC title

• A61L31/16 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title