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Electrospun PNIPAAm/PCL fiber mats for aligned cell sheets
US11111611B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11111611-B2 |
| Application number | US-201816023147-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 29, 2018 |
| Priority date | Jun 30, 2017 |
| Publication date | Sep 7, 2021 |
| Grant date | Sep 7, 2021 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (ε-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential to generate tissue-specific, aligned cell sheets for transplant studies.
First claim
Opening claim text (preview).
What is claimed is: 1. A fiber mat comprising poly(N-isopropylacrylamide) (PNIPAAm) and poly(caprolactone) (PCL), wherein PNIPAAm content is at least 90%. 2. The fiber mat of claim 1 , having fibers with a diameter between about 1 and 3 μm. 3. The fiber mat of claim 1 , having fibers formed from a PNIPAAm core and a PCL shell. 4. The fiber mat of claim 1 , having PNIPAAm fibers and PCL fibers. 5. The fiber mat of claim 1 , having fibers arranged substantially in parallel.
Assignees
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Classifications
- D04H1/43828Primary
sheath-core · CPC title
Mixed fibres, e.g. at least two chemically different fibres or fibre blends · CPC title
General culture methods using substrates (for specific animal cell type C12N5/06) · CPC title
Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth · CPC title
Ultrafine fibres, e.g. microfibres · CPC title
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- What does patent US11111611B2 cover?
- The present invention provides compositions comprising aligned fibers of electrospun PNIPAAm and poly (ε-caprolactone) (PCL) (denoted PNIPAAm/PCL fibers). The PNIPAAm/PCL compositions enable enhanced growth and detachment of intact anisotropic cell sheets. The compositions do not require chemical modification or resource-intensive techniques, thus saving time and expense, and have the potential…
- Who is the assignee on this patent?
- Univ Texas
- What technology area does this patent fall under?
- Primary CPC classification D04H1/43828. Mapped technology areas include Textiles & Paper.
- When was this patent published?
- Publication date Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).