Method for preparing sitagliptin intermediate via asymmetrical reduction method
US-10189760-B2 · Jan 29, 2019 · US
US11110444B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11110444-B2 |
| Application number | US-201916730345-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 30, 2019 |
| Priority date | Dec 30, 2019 |
| Publication date | Sep 7, 2021 |
| Grant date | Sep 7, 2021 |
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A chiral catalyst represented by formula (II) is provided. In formula (II), Y independently includes hydrogen, fluorine, trifluoromethyl, isopropyl, tert-butyl, CmH2m+1 or OCmH2m+1, wherein m=1-10 and n=1-10. A heterogeneous chiral catalyst is also provided. The heterogeneous chiral catalyst includes the chiral catalyst represented by formula (II), and a substrate connected to the chiral catalyst.
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What is claimed is: 1. A chiral catalyst, represented by formula (I): wherein Y independently comprises hydrogen, fluorine, trifluoromethyl, isopropyl, tert-butyl, C m H 2m+1 or OC m H 2m+1 , wherein m=1-10 and n=1-10. 2. The chiral catalyst as claimed in claim 1 , wherein Y independently comprises hydrogen, CH 3 or OCH 3 , and n=3-8. 3. The chiral catalyst as claimed in claim 1 , wherein the chiral catalyst comprises: 4. A chiral catalyst, represented by formula (II): wherein Y independently comprises hydrogen, fluorine, trifluoromethyl, isopropyl, tert-butyl, C m H 2m+1 or OC m H 2m+1 , wherein m=1-10 and n=1-10. 5. The chiral catalyst as claimed in claim 4 , wherein Y independently comprises hydrogen, CH 3 or OCH 3 , and n=3-8. 6. The chiral catalyst as claimed in claim 4 , wherein the chiral catalyst comprises: 7. A heterogeneous chiral catalyst, comprising: a chiral catalyst as claimed in claim 4 ; and a substrate connected to the chiral catalyst. 8. The heterogeneous chiral catalyst as claimed in claim 7 , wherein the surface of the substrate comprises hydroxyl groups. 9. The heterogeneous chiral catalyst as claimed in claim 8 , wherein the substrate comprises silicon oxide, titanium oxide, iron oxide, zinc oxide or aluminum oxide. 10. The heterogeneous chiral catalyst as claimed in claim 9 , wherein the substrate has a specific surface area which is in a range from 10 m 2 /g to 1,000 m 2 /g. 11. The heterogeneous chiral catalyst as claimed in claim 9 , wherein the substrate has a pore size which is in a range from 2 nm to 50 nm. 12. The heterogeneous chiral catalyst as claimed in claim 8 , wherein the hydroxyl group of the substrate is connected to the Si(OEt) 3 group of the chiral catalyst. 13. The heterogeneous chiral catalyst as claimed in claim 12 , wherein a silicon-oxygen bond is formed between the substrate and the chiral catalyst.
containing silicon (ligands in coordination complexes B01J31/1608) · CPC title
Silica · CPC title
also containing elements or functional groups covered by B01J31/0201 - B01J31/0269 · CPC title
on mineral substrates · CPC title
containing three or more hetero rings · CPC title
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