Ciprofloxacin polymorph and its use

Patent metadata

Field	Value
Publication number	US-11104663-B2
Application number	US-201816650670-A
Country	US
Kind code	B2
Filing date	Sep 28, 2018
Priority date	Sep 29, 2017
Publication date	Aug 31, 2021
Grant date	Aug 31, 2021

Abstract

The present disclosure relates to ciprofloxacin polymorphs and their use in treating infections.

First claim

What is claimed is:

1. A polymorph of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)1,4-dihydroquinoline-3-carboxylic acid characterized in that it provides an XRPD pattern comprising peaks at about 9.0 (2θ degrees), about 23.2 (2θ degrees), about 26.9 (2θ degrees), about 9.3 (2θ degrees), about 18.7 (2θ degrees), about 27.6 (2θ degrees), about 15.48 (2θ degrees), about 15.781 (2θ degrees) about 20.041 (2θ degrees), about 11.535 (2θ degrees), and about 12.982 (2θ degrees).

2. The polymorph of claim 1 , characterized in that it provides an XRPD pattern in accordance with that shown in FIG. 6 , and/or comprising peaks substantially as set out in Table 4.

3. A composition, comprising particles including the polymorph of claim 1 , wherein the particles have a mean particle size (volume-based distribution) in the range of about 0.5 μm to about 10 μm.

4. The composition of claim 3 , wherein the particles have a mean particle size (volume-based distribution) in the range of about 0.5 μm to about 7 μm.

5. The composition of claim 3 , wherein the particles are uncoated.

6. The composition of claim 3 , wherein the composition comprises dry powder or aerosol droplets of the particles, wherein the dry powder or aerosol droplets have a mass median aerodynamic diameter (MMAD) of between about 0.5 μm to about 6 μm diameter.

7. A pharmaceutical composition comprising:
(a) the particles of claim 3 ; and
(b) a pharmaceutically acceptable carrier.

8. A method for treating a bacterial infection, comprising administering to a subject in need thereof an amount effective to treat the bacterial infection of the composition of claim 3 .

9. The method of claim 8 , wherein the bacterial infection comprises a bacterial infection selected from the group consisting of infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, infectious diarrhea, urinary tract infections, typhoid fever, prostatitis, anthrax, and chancroid.

10. The method of claim 8 , wherein the bacterial infection comprises a respiratory tract infection.

11. The method of claim 10 , wherein the respiratory tract infection comprises bronchitis and/or pneumonia.

12. The method of claim 8 , wherein the composition is delivered via pulmonary administration.

13. The method of claim 12 , wherein the pulmonary administration comprises inhalation or nebulization, and wherein the inhalation or nebulization results in pulmonary delivery to the subject of dry powder or aerosol droplets of the composition.

14. The method of claim 12 , wherein the composition is administered as a dry powder, or as aerosol droplets having a mass median aerodynamic diameter (MMAD) of between about 0.5 μm to about 6 μm diameter.

15. A method of preparing polymorph particles of claim 3 , comprising
(a) obtaining a solution or a suspension of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid in a solvent or mixture of solvents;
(b) feeding and spraying said solution or suspension into a pressurized chamber to obtain a stream of atomized droplets; and
(c) removing the solvent or mixture of solvents from said droplets to form the polymorph particles.

16. The method of claim 15 wherein the solvent is hexafluoroisopropanol.

17. The method of claim 16 , wherein the solution or suspension has concentration of 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid in the range of 10 mg/mL and 100 mg/mL.

18. The method of claim 15 , wherein spraying is through a nozzle orifice having a diameter in the range of 20 μm and 125 μm.

19. The method of claim 18 , wherein the nozzle orifice is placed between 2 mm and 20 mm from a sonic energy source located within the stream.

Assignees

• Crititech Inc

Inventors

• Williams Mark
• Sittenauer Jacob
• Clark Shelby
• Farthing Joseph
• Baltezor Michael
• Mcclorey Matthew

Classifications

• A61K9/0073

  Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; (nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M) · CPC title

• C07D401/10 Primary

  linked by a carbon chain containing aromatic rings · CPC title

• A61K9/14

  Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)} · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• C07D215/56 Primary

  with oxygen atoms in position 4 · CPC title