Micronized placental tissue compositions and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-11103536-B2
Application number	US-201916520909-A
Country	US
Kind code	B2
Filing date	Jul 24, 2019
Priority date	Feb 14, 2011
Publication date	Aug 31, 2021
Grant date	Aug 31, 2021

Abstract

Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.

First claim

What is claimed:

1. A method for promoting wound healing, wherein the method comprises contacting a wound with a composition comprising micronized placental tissue particles, said tissue particles consisting essentially of an amnion layer and a chorion layer, wherein the chorion layer is layered directly over the amnion layer, wherein the intermediate layer has been substantially removed, wherein the amnion layer has an epithelial layer and an exposed fibroblast layer, and further wherein the wound healing is associated with an orthopedic application.

2. The method of claim 1 , wherein the orthopedic application is selected from the group consisting of tendon repair, aiding in the repair of periosteum, repair of ruptured/damaged bursa, securing void filling materials during bone repair, repair of an articular surface, repair of a soft-tissue injury in or around a joint, application to an articular surface, repair and/or regrow chondrocytes, and as an anti-adhesion barrier.

3. The method of claim 2 , wherein the soft-tissue injury is caused by trauma or repeated motion.

4. The method of claim 1 , wherein the micronized placental tissue particles are dehydrated.

5. The method of claim 1 , wherein the composition is an injectable composition.

6. The method of claim 1 , wherein the micronized placental tissue particles are less than 500 μm.

7. The method of claim 6 , wherein the micronized placental tissue particles are less than 300 μm.

8. The method of claim 7 , wherein the micronized placental tissue particles are 25-150 μm.

Assignees

• Mimedx Group Inc

Inventors

• Morse Brenda S
• Sith Somaly
• Spencer Randall
• Ray Steven
• Daniel John
• Tofe Robert

Classifications

• A61L27/3604

  characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L2430/34

  for soft tissue reconstruction · CPC title

• A61L27/3695

  characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this (A61L27/3687, A61L27/3691 take precedence) · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title