Crystalline salts of (s)-6-((1-acetylpiperidin-4-yl)amino)-n-(3-(3,4-dihydroisoquinolin-2(1h)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide
US-2017190688-A1 · Jul 6, 2017 · US
US11098059B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11098059-B2 |
| Application number | US-201816762114-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 5, 2018 |
| Priority date | Nov 8, 2017 |
| Publication date | Aug 24, 2021 |
| Grant date | Aug 24, 2021 |
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The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.
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What is claimed is: 1. A compound selected from one of the following, or a pharmaceutically acceptable salt thereof. 2. A composition for treating cancer comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. 3. A method for treating cancer comprising administering to a patient in need thereof a composition of claim 2 .
containing isoquinuclidine ring systems · CPC title
containing three or more hetero rings · CPC title
Bridged systems · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
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