Cysteine engineered antibodies and conjugates
US-2015017188-A1 · Jan 15, 2015 · US
4-azapodophylotoxins compounds
US11098052B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11098052-B2 |
| Application number | US-201716081683-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 2, 2017 |
| Priority date | Mar 2, 2016 |
| Publication date | Aug 24, 2021 |
| Grant date | Aug 24, 2021 |
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- Title
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- Abstract
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Abstract
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The present disclosure relates to 4-azapodophylotoxins compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions.
First claim
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What is claimed is: 1. A compound selected from the group consisting of: 6,7-Methylenedioxy-4-(cyclobutyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 17); 6,7-Methylenedioxy-4-(cyclopentyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 18); 6,7-Methylenedioxy-4-(cyclohexyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 19); 6,7-Methylenedioxy-4-(2-piperidin-1-yl-ethyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 21); 6,7-Methylenedioxy-4-(2-morpholin-4-yl-ethyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 22); 6,7-Methylenedioxy-4-(cyclopentyl)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 30); and a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. 3. A method for treating cancer in a patient in need thereof comprising administering to the patient a compound of claim 1 , wherein the compound is administered in an amount effective to treat cancer. 4. The compound of claim 1 , wherein the compound is selected from the group consisting of: 6,7-Methylenedioxy-4-(cyclobutyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 17); 6,7-Methylenedioxy-4-(cyclopentyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 18); 6,7-Methylenedioxy-4-(cyclohexyl)-9-(3,4,5-trimethoxyphenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 19); 6,7-Methylenedioxy-4-(cyclopentyl)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one (Compound 30); and a pharmaceutically acceptable salt thereof.
Assignees
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Classifications
Antineoplastic agents · CPC title
the condensed system containing two rings with oxygen as ring hetero atom and one ring with nitrogen as ring hetero atom · CPC title
Ortho-condensed systems · CPC title
- C07D491/048Primary
the oxygen-containing ring being five-membered · CPC title
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- What does patent US11098052B2 cover?
- The present disclosure relates to 4-azapodophylotoxins compounds, pharmaceutical compositions comprising such compounds, kits, and methods for using such compounds or pharmaceutical compositions.
- Who is the assignee on this patent?
- Pettit George Robert, Univ Arizona State
- What technology area does this patent fall under?
- Primary CPC classification C07D491/048. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 24 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).