Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (mnk1) and 2 (mnk2)
US-2017121326-A1 · May 4, 2017 · US
US11098030B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11098030-B2 |
| Application number | US-201916703544-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 4, 2019 |
| Priority date | May 26, 2016 |
| Publication date | Aug 24, 2021 |
| Grant date | Aug 24, 2021 |
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Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.
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What is claimed is: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt of any of the foregoing. 2. The compound of claim 1 , wherein the compound is or a pharmaceutically acceptable salt thereof. 3. The compound of claim 2 , wherein the compound is 4. The compound of claim 1 , wherein the compound is or a pharmaceutically acceptable salt thereof. 5. The compound of claim 4 , wherein the compound is 6. The compound of claim 1 , wherein the compound is or a pharmaceutically acceptable salt thereof. 7. The compound of claim 6 , wherein the compound is 8. The compound of claim 1 , wherein the compound is or a pharmaceutically acceptable salt thereof. 9. The compound of claim 8 , wherein the compound is 10. The compound of claim 1 , wherein the compound is or a pharmaceutically acceptable salt thereof. 11. The compound of claim 10 , wherein the compound is 12. The compound of claim 1 , wherein the compound is or a pharmaceutically acceptable salt thereof. 13. The compound of claim 12 , wherein the compound is
Ortho-condensed systems · CPC title
directly linked by a ring-member-to-ring-member bond · CPC title
Antineoplastic agents · CPC title
not condensed and containing further heterocyclic rings · CPC title
Indoles, e.g. pindolol · CPC title
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