Heart tissue surface contour-based radiosurgical treatment planning

Patent metadata

Field	Value
Publication number	US-11097127-B2
Application number	US-201816194751-A
Country	US
Kind code	B2
Filing date	Nov 19, 2018
Priority date	Jul 17, 2009
Publication date	Aug 24, 2021
Grant date	Aug 24, 2021

Abstract

A system that generates a three-dimensional model of a tissue surface, for example the inner surface of the heart from two-dimensional image data slices. On this surface, one or more pattern lines are drawn, e.g., by a physician using a user interface, to designate desired lesion(s) on the surface. From the pattern lines, a three-dimensional volume for a lesion can be determined using known constraints. Advantageously, the series of boundaries generated by the three-dimensional volume may be projected back onto the individual CT scans, which then may be transferred to a standard radiosurgical planning tool. A dose cloud may also be projected on the model to aid in evaluating a plan.

First claim

What is claimed is:

1. A radiosurgical method for treating a patient body having a heart, the heart having a non-tumerous disease, the method comprising:
acquiring three-dimensional image data from the heart;
generating a three-dimensional model of a tissue surface of the heart utilizing the image data;
receiving user input on the surface model of a desired ionizing radiation treatment lesion pattern for mitigating the disease; and
outputting information regarding a planned lesion pattern relative to the three-dimensional image data based upon the desired lesion pattern.

2. The method of claim 1 , wherein generating the three-dimensional model comprises generating a model of the heart based upon a boundary between blood and tissue of the heart.

3. The method of claim 2 , wherein the boundary comprises an inner surface of the heart tissue.

4. The method of claim 2 , wherein the three-dimensional image data from the heart comprises a plurality of slices of two-dimensional data, and wherein generating the three-dimensional model comprises generating a model of the heart based upon segments of the boundary between the blood and the heart tissue in each slice of the two dimensional data.

5. The method of claim 4 , wherein the three-dimensional model is formed by stacking or assembling together the segments, and by extending the surface between the segments.

6. The method of claim 4 , wherein outputting comprises projecting the lesion pattern onto each of the plurality of slices of two-dimensional data.

7. The method of claim 1 , wherein the three-dimensional image data from the heart comprises a plurality of slices of two-dimensional data, and wherein outputting comprises projecting the lesion pattern onto each of the plurality of slices of two-dimensional data.

8. The method of claim 1 , further comprising generating a three-dimensional volume for a lesion based upon the user input, and generating the information based upon the three-dimensional volume.

9. The method of claim 8 , wherein generating the volume comprises expanding the user input to a width that is sufficient to inhibit contractile pathways.

10. The method of claim 8 , wherein generating the volume comprises expanding the user input to a depth that is sufficient to transmurally penetrate through the tissue of the heart.

11. The method of claim 8 , wherein generating the volume comprises expanding the user input to cover an area of tissue of interest at which the treatment is to occur.

12. The method of claim 1 , further comprising generating an ionizing radiation treatment plan based upon the information, and projecting a dose cloud to the solid model based upon the treatment plan.

13. The method of claim 12 , further comprising snapping the user input on the lesion pattern to the surface of the model.

14. The method of claim 13 , further comprising evaluating the dose cloud with respect to the user input to determine sufficient treatment.

15. The method of claim 14 , wherein evaluating comprises walking the dose cloud around the surface to confirm that the loop forms an enclosed perimeter around the surface.

16. The method of claim 15 , wherein walking comprises evaluating a thickness of the loop with respect to a threshold.

17. A radiosurgical method for treating a patient body having a heart, the heart having a non-tumerous disease, the method comprising:
acquiring three-dimensional image data from the heart;
generating a three-dimensional model of a tissue surface of the heart utilizing the image data;
receiving user input on the surface model of a desired ionizing radiation treatment lesion pattern for mitigating the disease; and
generating an ionizing radiation treatment plan based upon the desired lesion pattern, and projecting a dose cloud relative to the image data based upon the desired treatment plan.

18. The method of claim 17 , further comprising snapping the user input for the lesion pattern to the surface of the model.

19. A radiosurgical system for treating a patient body with a heart, the heart having a non-tumerous disease, the system comprising:
an image capture device for acquiring three-dimensional planning image data from the heart; and
a processor system comprising a modeling module coupled to the image data for generating a surface model of the heart based upon the image data, and an input for identifying a target region of the heart on the surface model, the processor system coupling the input to the modeling module so as to generate a lesion pattern on the image data in response to the input on the surface model.

20. The apparatus of claim 19 , wherein the modeling module is configured to generate the three-dimensional model of the heart based upon a boundary between blood and tissue of the heart.

21. A method for determining one or more cardiac arrhythmia targets for ablation, the method comprising:
receiving a first set of image data;
receiving an indication of an abnormality in a second set of image data; and
defining the one or more cardiac arrhythmia targets based on the first and second sets of image data; wherein defining the one or more cardiac arrhythmia targets includes determining a dose pattern within and around the target.

22. A computer-implemented method for identifying cardiac arrhythmia targets, the method comprising:
receiving three-dimensional image data from the heart of a patient;
receiving a user input related to desired lesion; and
forming, based on the three-dimensional image data from the heart of the patient and the received user input, a model of a three-dimensional lesion; wherein forming the model of the three-dimensional lesion comprises determining a dose pattern within and around the lesion.

Assignees

• Varian Med Sys Inc

Inventors

• Sumanaweera Thilaka
• Gardner Ed
• Blanck Oliver
• Cai Tao
• Uecker Darrin
• Maguire Patrick

Classifications

• A61N5/1039 Primary

  using functional images, e.g. PET or MRI · CPC title

• A61N5/103 Primary

  Treatment planning systems · CPC title

• A61B2034/107

  Visualisation of planned trajectories or target regions · CPC title

• A61B2034/105

  Modelling of the patient, e.g. for ligaments or bones · CPC title

• A61B2034/104

  Modelling the effect of the tool, e.g. the effect of an implanted prosthesis or for predicting the effect of ablation or burring · CPC title