Nose-to-brain drug delivery device

Patent metadata

Field	Value
Publication number	US-11097073-B2
Application number	US-201816193696-A
Country	US
Kind code	B2
Filing date	Nov 16, 2018
Priority date	May 17, 2016
Publication date	Aug 24, 2021
Grant date	Aug 24, 2021

Abstract

A nose-to-brain drug delivery device is provided. The nose-to-brain drug delivery device includes a freeze-dried drug container for storing a freeze-dried drug, a restoring solvent container for storing a solvent for thawing the freeze-dried drug, a membrane for preventing the freeze-dried drug from being mixed with the solvent, and a compressor for providing a driving force. The membrane is opened by the driving force of the compressor to mix the freeze-dried drug with the solvent, thereby thawing the freeze-dried drug, and the thawed drug is sprayed by the driving force of the compressor.

First claim

What is claimed is:

1. A nose-to-brain drug delivery device comprising:
a freeze-dried drug container for storing a freeze-dried drug;
a restoring solvent container for storing a solvent for reconstituting the freeze-dried drug;
a membrane for preventing the freeze-dried drug from being mixed with the solvent; and
a compressor for providing a driving force,
wherein the membrane is opened by the driving force of the compressor to mix the freeze-dried drug with the solvent, thereby reconstituting the freeze-dried drug, and the reconstituted drug is capable of being sprayed by the driving force of the compressor,
wherein the reconstituted drug is capable of being sprayed into a nose of a subject in a mecca position state where a head of the subject faces a chest of the subject,
wherein a propellant movement path is provided between the compressor and the restoring solvent container and provides a flow path for compressed gas stored in the compressor,
wherein the restoring solvent container is formed of a flexible material and is deformed by the driving force to increase an internal pressure of the restoring solvent container, and the membrane is capable of being opened by the increased internal pressure,
wherein one end of the restoring solvent container includes a receiving recess in which one end of the propellant movement path is inserted, and
wherein the compressed gas released from the one end of the propellant movement path into the receiving recess is capable of pushing the one end of the restoring solvent container in at least two directions.

2. The nose-to-brain drug delivery device of claim 1 , wherein the compressor provides the driving force to the one end of the restoring solvent container, and another end of the restoring solvent container is blocked by the membrane so as to be separated from the freeze-dried drug container.

3. The nose-to-brain drug delivery device of claim 1 , wherein the freeze-dried drug container includes a fine hole for spraying the reconstituted drug.

4. The nose-to-brain drug delivery device of claim 3 , further comprising:
a spray unit,
wherein the drug released from the fine hole is capable of being sprayed outward through the spray unit.

5. The nose-to-brain drug delivery device of claim 1 , wherein the restoring solvent container, the membrane, and the freeze-dried drug container are disposed in the order named, from the compressor.

6. The nose-to-brain drug delivery device of claim 1 , further comprising:
a first housing in which the compressor is received; and
a second housing in which the restoring solvent container, the membrane, and the freeze-dried drug container are received,
wherein the second housing is detachable from the first housing, and a longitudinal direction of the first housing forms an acute angle with a longitudinal direction of the second housing when the first housing is coupled to the second housing.

7. The nose-to-brain drug delivery device of claim 1 ,
wherein a spray pressure of the reconstituted drug ranges from 6 psi to 20 psi.

8. The nose-to-brain drug delivery device of claim 7 , wherein the spray pressure of the reconstituted drug ranges from 6 psi to 15 psi.

Assignees

• Iucf Hyu

Inventors

• Lee Sang-Kyung
• Chung Kun Ho
• Ullah Irfan
• Kumar Priti
• Lee Sangah

Classifications

• A61M11/008

  by squeezing, e.g. using a flexible bottle or a bulb · CPC title

• A61M15/0031

  by bursting or breaking the package, i.e. without cutting or piercing · CPC title

• A61M2210/0693

  Brain, cerebrum · CPC title

• A61M11/007

  Syringe-type or piston-type sprayers or atomisers · CPC title

• A61M15/003

  using capsules, e.g. to be perforated or broken-up · CPC title