Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds

Patent metadata

Field	Value
Publication number	US-11090409-B2
Application number	US-201815982769-A
Country	US
Kind code	B2
Filing date	May 17, 2018
Priority date	Apr 9, 2010
Publication date	Aug 17, 2021
Grant date	Aug 17, 2021

Abstract

According to an illustrative embodiment a method to promote healing of a wound is provided comprising contacting the wound with a biologically active composition comprising a lipoic acid derivative and gelatin. In another embodiment a wound dressing is provided comprising a scaffold coated with a biologically active composition comprising a lipoic acid derivative. In a further embodiment, a system is provided for treating a tissue site of a patient, the system comprising a reduced-pressure source to supply reduced pressure, a manifold to distribute reduced pressure to a tissue site and a scaffold coated with a biologically active composition comprising a lipoic acid derivative. Methods for producing such a system and scaffold are also disclosed.

First claim

We claim:

1. A reduced-pressure therapy system for treating a tissue site, comprising:
a manifold at least partially coated with a composition comprising a gelatin substrate, a lipoic acid derivative, and a chelating agent, wherein the composition reduces excessive matrix metalloprotease activity, and wherein the lipoic acid derivative has the structure:

wherein n 1 and n 2 are, independently, C 1 -C 10 alkyl; and R 1 is H, C 1 -C 10 alkyl, C 6 -C 14 aryl, an alkyl ammonium or a protonated amino acid;

a drape adapted to provide a sealed space around the manifold and the tissue site; and
a reduced-pressure source configured to deliver reduced pressure to the sealed space.

2. The system of claim 1 , further comprising a scaffold adapted to be positioned between the manifold and the tissue site, wherein the scaffold has a plurality of passages.

3. The system of claim 2 , wherein the scaffold comprises polyurethane or collagen.

4. The system of claim 2 , further comprising a release layer adapted to be positioned between the scaffold and the manifold.

5. The system of claim 1 , further comprising an interface for fluidly coupling the reduced-pressure source to the sealed space.

6. The system of claim 1 , wherein the lipoic acid derivative comprises alpha-lipoic acid or sodium lipoate.

7. The system of claim 1 , wherein the chelating agent comprises ethylenediaminetetraacetic acid.

8. The system of claim 1 , wherein the composition further comprises an antimicrobial agent, a growth factor, or a preservative.

9. The system of claim 8 , wherein the antimicrobial agent is non-ionic silver, polyhexamethylene biguanide, chlorhexidine, benzalconium chloride, or triclosan.

10. The system of claim 1 , wherein the composition further preserves granulation tissue.

11. The system of claim 1 , wherein the composition is formulated for time-controlled release of the lipoic acid derivative.

12. The system of claim 1 , wherein the composition comprises 0.1% to 25% w/w gelatin substrate.

13. The system of claim 1 , wherein the composition comprises a bloom value of between about 150-300 g.

14. The system of claim 1 , wherein the composition comprises a bloom value of between about 200-250 g.

15. The system of claim 1 , wherein the composition comprises a bloom value of about 225 g.

Assignees

• Kci Licensing Inc

Inventors

• Zimnitsky Dmitry
• Finkbiner Jenny
• Sanders Blane

Classifications

• A61M1/85

  with gas or fluid supply means, e.g. for supplying rinsing fluids or anticoagulants (for negative pressure wound therapy A61M1/92, A61M1/94; combined with tracheal tubes A61M16/0463; dental instruments with combined rinsing and aspirating A61C17/0208) · CPC title

• A61M1/92

  with liquid supply means · CPC title

• A61M1/915

  Constructional details of the pressure distribution manifold · CPC title

• A61K31/381

  having five-membered rings · CPC title

• A61K31/14

  Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205) · CPC title