Combination cellulose material and method of making same

Patent metadata

Field	Value
Publication number	US-11083822-B2
Application number	US-201515327234-A
Country	US
Kind code	B2
Filing date	Jul 17, 2015
Priority date	Jul 18, 2014
Publication date	Aug 10, 2021
Grant date	Aug 10, 2021

Abstract

Combination cellulose materials and methods of making and using these materials. The combination material includes a first cellulosic material and a second cellulosic material.

First claim

The invention claimed is:

1. A composite material comprising a mixture of:
i. a first gel component, the first gel component comprising a carboxymethyl cellulose having a molecular weight average of about 100 to about 300 kDa, wherein the carboxymethyl cellulose is present at from about 3 to about 6 percent by weight of the first gel component;
ii. a second powder component, the second powder component comprising a dry cellulose material, wherein the cellulose material comprises oxidized regenerated cellulose having a localized pH of from about 2.5 to about 4.5; and
iii. an aqueous component;

wherein the composite material has a pH of 3 or lower.

2. The material of claim 1 , wherein the first gel component further comprises by weight percentage of the first gel component, from about 0.5 percent to about 1.0 percent salt.

3. The material of claim 1 , wherein the dry cellulose material has a localized pH in a range of from about 2 to about 3.

4. The material of claim 1 , wherein the carboxymethylcellulose has a molecular weight average of about 25 kDa with a 0.7 substitution.

5. The material of claim 1 , wherein the composite material comprises by weight of the composite material:
i. from about 25 percent to about 80 percent of the first gel component; and
ii. from about 0.1 to about 25 percent of the second powder component.

6. The material of claim 1 , wherein the second powder component comprises lyophilized oxidized regenerated cellulose.

7. The material of claim 1 , wherein the composite material is a sterile, flowable gel.

8. A composite material comprising a mixture of:
i. a first gel component, the first gel component comprising carboxymethyl cellulose having a molecular weight average of about 100 to about 300 kDa in an amount of from about 3 to about 6 percent by weight of the first gel component;
ii. a second powder component comprising a dry cellulose material; and
iii. an aqueous component;

wherein the composite material;
a. has a pH of 3 or lower; and
b. is a sterile, flowable gel.

9. The material of claim 8 , wherein the first gel component further comprises by weight percentage of the first gel component, from about 0.5 percent to about 1.0 percent salt.

10. The material of claim 8 , wherein the dry cellulose material is in the form of fibers.

11. The material of claim 8 , wherein the dry cellulose material comprises oxidized regenerated cellulose micro-fibers having a localized pH of about 2.5 to about 4.5.

12. The material of claim 8 , wherein the dry cellulose material has a localized pH in a range of from about 2 to about 3.

13. The material of claim 8 , wherein the carboxymethylcellulose has a molecular weight average of about 25 kDa with a 0.7 substitution.

14. The material of claim 8 , wherein the composite material comprises by weight of the composite material:
i. from about 25 percent to about 80 percent of the first gel component; and
ii. from about 0.1 to about 25 percent of the second powder component.

15. The material of claim 8 , wherein the second powder component comprises lyophilized oxidized regenerated cellulose.

16. A composite material having a pH of 3 or lower, the composite material comprising a mixture of:
i. a first gel component, the first gel component comprising carboxymethyl cellulose;
ii. a second powder component comprising a dry cellulose material and having a localized pH in a range of about 2 to about 3; and
iii. an aqueous component.

17. The material of claim 16 , wherein the first gel component comprises carboxymethyl cellulose having a molecular weight average of about 100 to about 300 kDa in an amount of about 3 to about 6 percent by weight of the first gel component.

18. The material of claim 16 , wherein the first gel component further comprises by weight percentage of the first gel component, from about 0.5 percent to about 1.0 percent salt.

19. The material of claim 16 , wherein the dry cellulose material is in the form of micro-fibers.

20. The material of claim 16 , wherein the second powder component comprises lyophilized oxidized regenerated cellulose.

Assignees

• Ethicon Inc

Inventors

• Smith Daniel J
• Vailhe Christophe

Classifications

• A61L24/0031

  Hydrogels or hydrocolloids · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L24/0042

  Materials resorbable by the body · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title