Shear-thinning compositions as an intravascular embolic agent

Patent metadata

Field	Value
Publication number	US-11083780-B2
Application number	US-201615746307-A
Country	US
Kind code	B2
Filing date	Jul 20, 2016
Priority date	Jul 20, 2015
Publication date	Aug 10, 2021
Grant date	Aug 10, 2021

Abstract

This disclosure relates to methods of using shear-thinning compositions in the treatment of a vascular disorders, cancers, infections, abscesses, and fistulas.

First claim

What is claimed is:

1. A method of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a shear-thinning composition comprising gelatin or a derivative thereof and silicate nanoparticles, wherein the composition does not further comprise a chemotherapeutic agent.

2. The method of claim 1 , wherein the patient is not further administered a chemotherapeutic agent.

3. The method of claim 1 , wherein the shear-thinning composition comprises about 0.5 percent to about 85 percent by weight of gelatin or a derivative thereof, and silicate nanoparticles together.

4. The method of claim 1 , wherein the shear-thinning composition comprises about 0.5 percent to about 20 percent by weight of the silicate nanoparticles.

5. The method of claim 1 , wherein the shear-thinning composition comprises about 0.5 percent to about 70 percent by weight of the gelatin or a derivative thereof.

6. The method of claim 1 , wherein the ratio of silicate nanoparticles to gelatin or a derivative thereof, is from about 0.1 to about 1.0.

7. The method of claim 1 , wherein the shear-thinning composition comprises:
about 6.75 percent by weight gelatin and about 2.25 percent by weight silicate nanoparticles; or
about 4.5 percent by weight gelatin and about 4.5 percent by weight silicate nanoparticles; or
about 2.25 percent by weight gelatin and about 6.75 percent by weight silicate nanoparticles; or
about 4.5 percent by weight gelatin and about 1.5 percent by weight silicate nanoparticles; or
about 3 percent by weight gelatin and about 3 percent by weight silicate nanoparticles; or
about 1.5 percent by weight gelatin and about 4.5 percent by weight silicate nanoparticles; or
about 2.25 percent by weight gelatin and about 0.75 percent by weight silicate nanoparticles; or
about 1.5 percent by weight gelatin and about 1.5 percent by weight silicate nanoparticles; or
about 0.75 percent by weight gelatin and about 2.25 percent by weight silicate nanoparticles.

8. The method of claim 1 , wherein the shear-thinning composition further comprises water.

9. The method of claim 8 , wherein the shear-thinning composition comprises about 0.5 percent to about 99 percent by weight of the water.

10. The method of claim 8 , wherein the shear-thinning composition comprises:
about 6.75 percent by weight gelatin, about 2.25 percent by weight silicate nanoparticles, and about 91 percent by weight water; or
about 4.5 percent by weight gelatin, about 4.5 percent by weight silicate nanoparticles, and about 91 percent by weight water; or
about 2.25 percent by weight gelatin, about 6.75 percent by weight silicate nanoparticles, and about 91 percent by weight water; or
about 4.5 percent by weight gelatin, about 1.5 percent by weight silicate nanoparticles, and about 94 percent by weight water; or
about 3 percent by weight gelatin, about 3 percent by weight silicate nanoparticles, and about 94 percent by weight water; or
about 1.5 percent by weight gelatin, about 4.5 percent by weight silicate nanoparticles, and about 94 percent by weight water; or
about 2.25 percent by weight gelatin, about 0.75 percent by weight silicate nanoparticles, and about 97 percent by weight water; or
about 1.5 percent by weight gelatin, about 1.5 percent by weight silicate nanoparticles, and about 97 percent by weight water; or
about 0.75 percent by weight gelatin, about 2.25 percent by weight silicate nanoparticles, and about 97 percent by weight water.

11. The method of claim 8 , wherein the shear-thinning composition is a hydrogel.

12. The method of claim 1 , wherein the gelatin is type-A porcine gelatin.

13. The method of claim 1 , wherein the yield stress of the shear-thinning composition is from about 1 Pa to about 200 Pa.

14. The method of claim 7 , wherein the shear-thinning composition comprises about 1.5 percent by weight gelatin and about 4.5 percent by weight silicate nanoparticles.

15. The method of claim 10 , wherein the shear-thinning composition comprises about 1.5 percent by weight gelatin, about 4.5 percent by weight silicate nanoparticles, and about 94 percent by weight water.

Assignees

• Brigham & Womens Hospital Inc
• Massachusetts Gen Hospital

Inventors

• Khademosseini Ali
• Oklu Rahmi

Classifications

• A61K38/39 Primary

  Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] · CPC title

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K47/02

  Inorganic compounds · CPC title