System and method for capacitance-based real-time micro-object position control with the aid of a digital computer

Patent metadata

Field	Value
Publication number	US-11079747-B2
Application number	US-202016734147-A
Country	US
Kind code	B2
Filing date	Jan 3, 2020
Priority date	Sep 19, 2016
Publication date	Aug 3, 2021
Grant date	Aug 3, 2021

Abstract

The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating control signals in the scheme.

First claim

What is claimed is:

1. A system for capacitance-based real-time micro-object position control with an aid of a digital computer, comprising:
at last one processor configured to execute computer-executable code and further configured to:
obtain one or more parameters of a system for positioning one or more micro-objects, the system comprising a plurality of electrodes, the electrodes configured to induce movements of the one or more micro-objects when the one or more micro-objects are suspended in a fluid proximate to the electrodes upon a generation of one or more forces by one or more of the electrodes;
model a capacitance of an interaction between each of the electrodes and at least one of the micro-objects as a function of a distance between that electrode and the at least one micro-object using dielectrophoretic forces acting upon that at least one micro-object, electrophoretic forces acting upon that at least one micro-object, and the system parameters comprising a viscous drag experienced by that at least one micro-object during the movements;
obtain a position of one or more of the micro-objects within the fluid; and
generate a control signal for each of the electrodes, the control signal comprising a command which generates one or more of the forces for a predefined period of time by that electrode, using the obtained position, the model, and a desired location of one or more of the micro-objects.

2. A system according to claim 1 , wherein that at least one micro-object remains at a constant height during the modeled interaction.

3. A system according to claim 1 , wherein acceleration of that at least one micro-object is not used during the modeling.

4. A system according to claim 1 , wherein the modeling further uses a stiction force acting upon that at least one micro-object.

5. A system according to claim 1 , wherein the electrodes and that at least one micro-object are represented as forming a capacitance electrical circuit in the model.

6. A system according to claim 1 , wherein the fluid is bounded by an enclosure and is on top of a layer of film.

7. A system according to claim 6 , wherein the layer of film is on top of the electrodes.

8. A system according to claim 6 , wherein the layer of film is laminated on top of the electrodes and that at least one micro-object touches a surface of the layer of film during the movements.

9. A system for capacitance-based real-time micro-object horizontal position control with an aid of a digital computer, comprising:
at least one processor configured to execute computer-executable code and further configured to:
obtain one or more parameters of a system for positioning one or more micro-objects, the system comprising a plurality of electrodes, the electrodes configured to induce movements of the one or more micro-objects along a film layer on top of the electrodes when the one or more micro-objects are suspended in a fluid on top of the film layer on top of the electrodes upon a generation of one or more forces by one or more of the electrodes;
model a capacitance of an interaction between each of the electrodes and at least one of the micro-objects as a function of a distance between that electrode and the at least one micro-object using dielectrophoretic forces acting upon that at least one micro-object, electrophoretic forces acting upon that at least one micro-object, and the system parameters comprising a drag against the film layer experienced by that at least one micro-object during the movements;
obtain a position of one or more of the micro-objects within the fluid; and
generate a control signal for each of the electrodes, the control signal comprising a command which generates one or re of the forces for a predefined period of time by that electrode, using the obtained position, the model, and a desired location of one or more of the micro-objects.

10. A system according to claim 9 , wherein that at least one micro-object remains at a constant height during the modeled interaction.

11. A system according to claim 9 , wherein the modeling further uses a stiction force acting upon that at least one micro-object.

12. A system according to claim 9 , wherein the electrodes and that at least one micro-object are represented as forming a capacitance electrical circuit in the model.

13. A method for capacitance-based real-time micro-object position control with an aid of a digital computer, comprising the steps of:
obtaining one or more parameters of a system for positioning one or more micro-objects, the system comprising a plurality of electrodes, the electrodes configured to induce movements of the one or more micro-objects when the one or more micro-objects are suspended in a fluid proximate to the electrodes upon a generation of one or more forces by the electrodes;
modeling a capacitance of an interaction between each of the electrodes and at least one of the micro-objects as a function of a distance between that electrode and the at least one micro-object using dielectrophoretic forces acting upon that at Last one micro-object, electrophoretic forces acting upon that at least one micro-object, and the system parameters comprising a viscous drag experienced by that at least one micro-object during the movements;
obtaining a position of one or more of the micro-objects within the fluid; and
generating a control signal for each of the electrodes, the control signal comprising a command which generates one or more of the forces for, a predefined period of time by that electrode, using the obtained position, the model, and a desired location of one or more of the micro-objects, wherein the steps are performed by a computer.

14. A method according to claim 13 , wherein that at least one micro-object remains at a constant height during the modeled interaction.

15. A method according to claim 13 , wherein acceleration of that at least one micro-object is not used during the modeling.

16. A method according to claim 13 , wherein the modeling further uses a stiction force acting upon that at least one micro-object.

17. A method according to claim 13 , wherein the electrodes and that at least one micro-object are represented as forming a capacitance electrical circuit in the model.

18. A method according to claim 13 , wherein the fluid is bounded by an enclosure and is on top of a layer of film.

19. A method according to claim 18 , wherein the layer of film is on top of the electrodes.

20. A method according to claim 18 , wherein the layer of film is laminated on top of the electrodes and that at least one micro-object touches a surface of the layer of film during the movements.

Assignees

• Palo Alto Res Ct Inc

Inventors

• Matei Ion
• Lu Jeng Ping
• Nelaturi Saigopal
• Bert Julie A
• Crawford Lara S
• Volkel Armin R
• Chow Eugene M

Classifications

• G05B17/02 Primary

  electric · CPC title

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• G05B2219/32359

  Modeling, simulating assembly operations · CPC title

• G06T7/194

  involving foreground-background segmentation · CPC title

• G06T7/74

  involving reference images or patches · CPC title